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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities.

Hybrid human--mouse Thy-1.1 genes were injected into pronuclei of Thy-1.2 mice to produce transgenic animals. A hybrid gene composed of the 5' part of the mouse Thy-1.1 gene combined with the 3' human untranslated regions was expressed abnormally in the kidney podocytes, which resulted in severe protein-uria and subsequent death in several founder mice. A hybrid Thy-1 gene composed of the human coding region with the 5' and 3' flanking regions of the mouse gene was expressed abnormally in a different part of the kidney (the tubular epithelia), which resulted in a proliferative kidney disorder. In addition, a neoplasm was found in the brain of one of these mice. These results show that the Thy-1 protein can play an important role in the activation, proliferation, and differentiation of many different cell types.[1]

References

  1. Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities. Kollias, G., Evans, D.J., Ritter, M., Beech, J., Morris, R., Grosveld, F. Cell (1987) [Pubmed]
 
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