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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Treatment of acid-peptic diseases by inhibition of gastric H+,K+-ATPase.

The substituted benzimidazoles are a new class of drugs with a unique antisecretory action. These agents have great potential for treatment of acid-peptic disease because they produce substantial, long-lasting inhibition of gastric acid secretion by inhibiting gastric H+,K+-ATPase in the gastric parietal cell. Clinical trials of omeprazole, a substituted benzimidazole, indicate that it is safe and effective for short-term treatment of patients with duodenal or gastric ulcer, and it is highly effective for long-term treatment of patients with Zollinger-Ellison syndrome.[1]

References

  1. Treatment of acid-peptic diseases by inhibition of gastric H+,K+-ATPase. McArthur, K.E., Jensen, R.T., Gardner, J.D. Annu. Rev. Med. (1986) [Pubmed]
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