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Inhibition of simian virus 40 DNA replication by specific modification of T-antigen with oxidized ATP.

We covalently bound periodate-oxidized ATP (oATP) to purified simian virus 40 (SV40) large T-antigen and determined the effect of this modification on viral DNA replication and three other biochemical activities of T-antigen. The oATP bound specifically to T-antigen, inhibiting the ATPase activity and preventing T-antigen from activating SV40 DNA replication in vitro. In contrast, binding of oATP had no effect on the DNA-binding activity of T-antigen nor on its ability to form a complex with DNA polymerase alpha. These results provide direct biochemical evidence suggesting that the T-antigen ATPase activity is necessary for viral DNA replication.[1]

References

  1. Inhibition of simian virus 40 DNA replication by specific modification of T-antigen with oxidized ATP. Smale, S.T., Tjian, R. J. Biol. Chem. (1986) [Pubmed]
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