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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Normal synthesis and expression of endothelial IIb/IIIa in Glanzmann's thrombasthenia.

Glanzmann's thrombasthenia is a bleeding disorder, inherited in an autosomal recessive way and characterized by an absence or deficiency of the platelet glycoprotein (GP) IIb/IIIa complex. Recently, we and others demonstrated that cultured human umbilical vein endothelial cells synthesized a membrane protein complex similar to the platelet GP IIb/IIIa complex. In this article, we demonstrate that endothelial cells isolated from the umbilical vein of a newborn with Glanzmann's thrombasthenia, as compared with normal endothelial cells, show no difference in their ability to synthesize and express this GP IIb/IIIa complex. Our results indicate that Glanzmann's thrombasthenia is not accompanied by an "endotheliopathy."[1]

References

  1. Normal synthesis and expression of endothelial IIb/IIIa in Glanzmann's thrombasthenia. Giltay, J.C., Leeksma, O.C., Breederveld, C., van Mourik, J.A. Blood (1987) [Pubmed]
 
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