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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Selective inhibition of DNA polymerase alpha by a polysaccharide purified from slime of Physarum polycephalum.

A polysaccharide was purified from the slime of a myxomycete, Physarum polycephalum, and its inhibitory effect on eukaryotic DNA polymerases was examined. Almost all the calf thymus DNA polymerase alpha activity was inhibited with higher than 0.2 mg/ml of the polysaccharide, when the assay was carried out with activated DNA as a template. The inhibitory effect occurred regardless of the amounts of the enzyme and deoxyribonucleotides, however, kinetic analysis revealed that the inhibition occurs competitively with the template DNA, the Ki value being 4 micrograms/ml. Inhibition was observed for DNA polymerase alpha, but not for DNA polymerases beta and gamma from various eukaryote species.[1]

References

  1. Selective inhibition of DNA polymerase alpha by a polysaccharide purified from slime of Physarum polycephalum. Shioda, M., Murakami-Murofushi, K. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
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