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Muscarinic receptor subtypes in hippocampus in Alzheimer's disease and mixed dementia type.

The relative proportion of super-high, high and low affinity agonist binding sites was measured in the hippocampus from individuals with dementia of the Alzheimer type (AD/SDAT), mixed (AD-MID) type and controls, using labelled quinuclidinyl benzilate ([3H]QNB) competing with unlabelled carbachol. A significant reduced number of [3H]QNB binding sites was obtained in dementia groups. A significant decrease in the proportion of super-high affinity agonist (V1) binding sites was found in the AD-MID group compared to controls while no change was found in the AD/SDAT group. The affinity constant (K1) for the V1 site was also significantly lower in the AD-MID group compared to controls.[1]

References

  1. Muscarinic receptor subtypes in hippocampus in Alzheimer's disease and mixed dementia type. Nordberg, A., Alafuzoff, I., Winblad, B. Neurosci. Lett. (1986) [Pubmed]
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