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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Stimulation of bone resorption in vitro by synthetic transforming growth factor-alpha.

Experiments were conducted to test the hypothesis that tumor-derived transforming growth factor-alpha (TGF-alpha) is responsible for the increased bone resorption and hypercalcemia seen in some malignant diseases. Homogeneous synthetic TGF-alpha prepared by the solid-phase synthesis method stimulated bone resorption directly in vitro in a concentration-dependent manner. Incubation times of 72 hours or more were required to stimulate resorption, which is similar to the time course of bone resorption by epidermal growth factor.[1]

References

  1. Stimulation of bone resorption in vitro by synthetic transforming growth factor-alpha. Ibbotson, K.J., Twardzik, D.R., D'Souza, S.M., Hargreaves, W.R., Todaro, G.J., Mundy, G.R. Science (1985) [Pubmed]
 
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