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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Bloomfield, C.D. et al.

In-vitro glucocorticoid studies for predicting response to glucocorticoid therapy in adults with malignant lymphoma.

Neoplastic tissues from 28 adults with malignant lymphoma were examined for glucocorticoid receptors and in-vitro sensitivity to glucocorticoids. The patients were then treated with desamethasone for 5--14 days. 13 patients achieved at least a partial remission, and 15 had no significant tumour response. Lymphoma cells from patients who responded had more glucocorticoid-receptor sites per cell and greater in-vitro sensitivity as measured by glucocorticoid inhibition of incorporation of leucine and uridine than did tumour cells from non-responders. Study of tumour glucocorticoid receptors and glucocorticoid sensitivity in vitro may allow selection of those patients with lymphoma who should receive glucocorticoids as part of combination chemotherapy.[1]

References

In-vitro glucocorticoid studies for predicting response to glucocorticoid therapy in adults with malignant lymphoma. Bloomfield, C.D., Smith, K.A., Peterson, B.A., Hildebrandt, L., Zaleskas, J., Gajl-Peczalska, K.J., Frizzera, G., Munck, A. Lancet (1980) [Pubmed]

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