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Young, R.H. et al.

Ovarian Sertoli-Leydig cell tumor with retiform and heterologous components. Report of a case with hepatocytic differentiation and elevated serum alpha-fetoprotein.

A 13-year-old girl had an ovarian Sertoli-Leydig cell tumor associated with marked elevation of the serum alpha-fetoprotein level. On microscopic examination, the tumor had a predominantly retiform pattern and in addition contained heterologous elements in the form of mucinous epithelium, skeletal muscle, and liver cells; alpha-fetoprotein was demonstrated within the liver cells by immunohistochemical techniques. The serum alpha-fetoprotein level fell postoperatively, but rose again when the tumor recurred. Despite radiation therapy and chemotherapy, the tumor pursued a rapidly malignant course and the patient died 9 months postoperatively.[1]

References

Ovarian Sertoli-Leydig cell tumor with retiform and heterologous components. Report of a case with hepatocytic differentiation and elevated serum alpha-fetoprotein. Young, R.H., Perez-Atayde, A.R., Scully, R.E. Am. J. Surg. Pathol. (1984) [Pubmed]

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