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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Trifluoperazine reversal of secretory diarrhea in pancreatic cholera.

Diarrhea in a patient with pancreatic cholera syndrome caused by a vasoactive intestinal polypeptide producing pancreatic islet-cell carcinoma responded rapidly and dramatically to the phenothiazine trifluoperazine. Treatment with intravenous somatostatin decreased the plasma vasoactive intestinal polypeptide level without changing the diarrhea. The chemotherapeutic agent chlorozotocin, the 2-chloroethyl analogue of streptozocin, caused a decrease in plasma vasoactive intestinal polypeptide but caused significant renal toxicity with proteinuria.[1]

References

  1. Trifluoperazine reversal of secretory diarrhea in pancreatic cholera. Donowitz, M., Elta, G., Bloom, S.R., Nathanson, L. Ann. Intern. Med. (1980) [Pubmed]
 
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