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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells.

When added to mouse neuroblastoma cultures, the potent tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) inhibits spontaneous neurite formation as well as that induced in response to serum deprivation, prostaglandin E1, 5-bromo-2'-deoxyuridine, and papaverine. Other tumor-promoting macrocyclic plant diterpenes also inhibit neurite formation, whereas nonpromoting diterpenes do not. Inhibition by TPA was reversible and was unrelated to toxicity.[1]

References

  1. Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells. Ishii, D.N., Fibach, E., Yamasaki, H., Weinstein, I.B. Science (1978) [Pubmed]
 
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