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Cortisol suppression and circadian rhythm in endogenous depression: a preliminary report.
We studied the relationships between dexamethasone challenge ( DST), 36-hr sleep deprivation (SD), and body temperature patterns in ten male endogenous depressives. Seven of the ten depressives were pre-SD DST non-suppressors, and five of the ten patients improved following SD. All five SD responders were pre-SD DST non-suppressors. Pre- and post-SD 12-hr daytime body temperature patterns defined three subgroups of depressives. SD responders with DST non-suppression showed a normal diurnal temperature pattern on both pre- and post-sleep deprivation. SD non-responders with DST non-suppression showed a diurnal variation, but time of maximum temperature value was phase-advanced before SD and delayed after SD. SD non-responders with DST suppression had a blunted diurnal temperature pattern on both pre- and post-SD. We conclude that a normal pre-SD temperature pattern together with pre-SD DST non-suppression may predict clinical response to SD suggesting the possibility of physiologically distinct subgroups of endogenous depressives.[1]References
- Cortisol suppression and circadian rhythm in endogenous depression: a preliminary report. Lee, M.A., Taylor, M.A. Biol. Psychiatry (1983) [Pubmed]
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