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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Serial plasma carcinoembryonic antigen measurements during treatment of metastatic breast cancer.

Serial plasma carcinoembryonic antigen ( CEA) levels were measured in 167 patients with metastatic breast cancer treated with fluorouracil, doxorubicin hydrochloride, and cyclophosphamide ( FAC). In 84 patients, the pretreatment CEA value was abnormal. Response rates and remission duration were similar in patients with normal and abnormal pretreatment levels. Carcinoembryonic antigen concentrations decreased in 94% of patients who responded to FAC therapy. The duration of response was 22 months for patients in whom the CEA levels normalized v nine months in those in whom it decreased but never returned to normal. Increasing CEA levels correlated with progressive disease in 87% of patients and preceded clinical evidence of progression in 77%. Serial CEA measurements can monitor response to chemotherapy, provide useful prognostic information of response duration, and detect progressive disease early.[1]

References

  1. Serial plasma carcinoembryonic antigen measurements during treatment of metastatic breast cancer. Mughal, A.W., Hortobagyi, G.N., Fritsche, H.A., Buzdar, A.U., Yap, H.Y., Blumenschein, G.R. JAMA (1983) [Pubmed]
 
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