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The immediate effects of cortisol on pulmonary function in normals and asthmatics.
We investigated short-term effects of corticosteroids on airway caliber, measured by spirometry and body plethysmography, over a period of 6 hr after an intravenous bolus of cortisol (8 mg/kg) or saline placebo was administered in a double-blind crossover format comparing 10 normal and nine asymptomatic unmedicated asthmatics. After 6 hrs isoproterenol (240 micrograms) was administered to compare the effects of cortisol with a beta-agonist bronchodilator. Serum cortisol levels remained greater than 100 micrograms/dl after cortisol and normal after placebo. Cortisol had no effect on pulmonary function except for a trend of improved flows and decreasing ratios of residual volume to total lung capacity in asthmatics that was not significant at 6 hr. Isoproterenol resulted in immediate improvement in specific conductance and flows in both groups; no interaction with cortisol was seen. We conclude that cortisol had no short-term effect on airway caliber in normals, at best a slowly evolving effect in asymptomatic unmedicated asthmatics, and no interaction with the bronchodilator effects of a maximal dose of isoproterenol in these groups.[1]References
- The immediate effects of cortisol on pulmonary function in normals and asthmatics. Ramsdell, J.W., Berry, C.C., Clausen, J.L. J. Allergy Clin. Immunol. (1983) [Pubmed]
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