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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Progesterone receptor level as a predictor of response to megestrol acetate in advanced breast cancer: a retrospective study.

Megestrol acetate (160 mg/day) produced a response rate of 44% in a retrospective series of 39 evaluable patients with advanced breast cancer. The estrogen-receptor (ER) level was greater than 10 fmols/mg of protein in 28 patients, and the progesterone-receptor (PR) level was greater than 10 fmols/mg of protein in 26 patients. ER and PR levels, age, and disease-free interval were analyzed for their relationship to response. The PR was the single best predictor of response to megestrol acetate; the addition of ER added 2% to the predictive accuracy rate of PR alone.[1]

References

  1. Progesterone receptor level as a predictor of response to megestrol acetate in advanced breast cancer: a retrospective study. Johnson, P.A., Bonomi, P.D., Anderson, K.M., Wolter, J.M., Bacon, L.D., Rossof, A.H., Economou, S.G. Cancer treatment reports. (1983) [Pubmed]
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