The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.
wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Anticonvulsant action of phenobarbital, diazepam, carbamazepine, and diphenylhydantoin in the electroshock test in mice after lesion of hippocampal pyramidal cells with intracerebroventricular kainic acid.

The electroshock test-taking hind limb tonic extension as the end point-was carried out on the fifth day after the intracerebroventricular injections of kainic acid (KA; 0.2 microgram per mouse). The following antiepileptics were tested for the anticonvulsant effects both in naive and KA-lesioned mice: phenobarbital (20 mg/kg), diazepam (8 mg/kg), carbamazepine (15 mg/kg) and diphenylhydantoin (10 mg/kg), all drugs being injected intraperitoneally 60 min before electroconvulsions. It was found that the protective effects of phenobarbital and diazepam were distinctly reduced in KA-lesioned animals when compared to naive mice. However, both carbamazepine and diphenylhydantoin protected KA-injected and control animals to a similar degree. Further, intracerebroventricular injections of KA resulted in the substantial loss of pyramidal cells in the whole CA3 field of the hippocampus. It is suggested that the intact hippocampus is necessary for the development of the full anticonvulsant effects of phenobarbital and diazepam, whilst the site of action of carbamazepine and diphenylhydantoin is independent of the hippocampus.[1]

References

  1. Anticonvulsant action of phenobarbital, diazepam, carbamazepine, and diphenylhydantoin in the electroshock test in mice after lesion of hippocampal pyramidal cells with intracerebroventricular kainic acid. Czuczwar, S.J., Turski, L., Kleinrok, Z. Epilepsia (1982) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Use
 

Editor

Share

Personal info

View

Links

About

Terms

 

WikiGenes - Universities