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Cerebroventricular propranolol elevates cerebrospinal fluid norepinephrine and lowers blood pressure.

Ventriculocisternal administration of dl- and d-propranolol produced dose-dependent increases in cerebrospinal fluid norepinephrine and reductions in blood pressure. A highly significant correlation was found between the increase in norepinephrine and the hypotensive effect. The propranolol-induced hypotension was prevented by intracisternal phentolamine. These data indicate that the hypotensive effect of centrally administered propranolol results from a drug-induced release of norepinephrine, which stimulates central alpha receptors to lower arterial pressure.[1]

References

  1. Cerebroventricular propranolol elevates cerebrospinal fluid norepinephrine and lowers blood pressure. Tackett, R.L., Webb, J.G., Privitera, P.J. Science (1981) [Pubmed]
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