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Proton magnetic resonance spectroscopic imaging in patients with frontal lobe epilepsy.

Proton magnetic resonance spectroscopic imaging (1H MRSI) has demonstrated decreased N-acetyl compounds ( NA) in the epileptogenic hippocampus in patients with temporal lobe epilepsy. We studied 8 patients with frontal lobe epilepsy and found mean NA/creatine (Cr) in the epileptogenic frontal lobe decreased by 27% compared with that of the contralateral homologous region (1.81 +/- 0.36 vs 2.49 +/- 0.60, p < 0.008). In every patient, NA/Cr was decreased in the epileptogenic region by at least 5%. These findings suggest that 1H MRSI may be useful in the presurgical evaluation of patients with frontal lobe epilepsy.[1]

References

  1. Proton magnetic resonance spectroscopic imaging in patients with frontal lobe epilepsy. Garcia, P.A., Laxer, K.D., van der Grond, J., Hugg, J.W., Matson, G.B., Weiner, M.W. Ann. Neurol. (1995) [Pubmed]
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