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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 

Role of interleukin-6 and transforming growth factor-beta in anorexia nervosa.

Anorexia nervosa is a serious eating disorder characterized by extreme weight loss and abnormalities of the neuroendocrine and immune systems. To determine the potential role of tumor necrosis factor-alpha ( TNF-alpha), interleukin-6 ( IL-6), and transforming growth factor-beta ( TGF-beta) in anorexia nervosa, serum concentrations of these cytokines were measured in patients with anorexia nervosa during starvation and after weight gain. Serum IL-6 and TGF-beta concentrations were both significantly elevated during starvation and returned to levels comparable to those of normal-weight controls by the end of therapy. In contrast, serum TNF-alpha levels were undetectable in all patients and controls. Cytokines may play previously unsuspected roles in anorexia nervosa and its complications.[1]

References

  1. Role of interleukin-6 and transforming growth factor-beta in anorexia nervosa. Pomeroy, C., Eckert, E., Hu, S., Eiken, B., Mentink, M., Crosby, R.D., Chao, C.C. Biol. Psychiatry (1994)
 
 
 
 
 
 
 
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