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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Endothelin-1 mRNA expression by peripheral blood monocytes in IgA nephropathy.

We investigated endothelin-1 mRNA expression in peripheral blood monocytes from 40 patients with IgA nephropathy, 40 with other glomerulonephritides and 10 with essential hypertension without renal diseases, and from 30 healthy age-matched controls. 95% of patients with IgA nephropathy had increased endothelin-1 mRNA expression in monocytes but little was detected from the other groups. Endothelin-1 mRNA was positively correlated with urinary protein excretion (95% CI 0.835-0.952) and histopathological findings (0.796-0.939). In 15 patients with IgA nephropathy endothelin-1 mRNA values and proteinuria decreased gradually after treatment. Endothelin-1 mRNA- expressing activated monocytes may be associated with the progression of IgA nephropathy.[1]

References

  1. Endothelin-1 mRNA expression by peripheral blood monocytes in IgA nephropathy. Nakamura, T., Ebihara, I., Shirato, I., Fukui, M., Tomino, Y., Koide, H. Lancet (1993) [Pubmed]
 
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