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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Two new cytotoxic chalcones from Calythropsis aurea.

The crude extract of Calythropsis aurea (Myrtaceae) produced a pattern of differential cytotoxicity in the NCI 60 cell line assay which was similar to those of known tubulin-interactive compounds. Cytotoxicity-guided fractionation led to the isolation of two new chalcones, calythropsin [1] and dihydrocalythropsin [2], which were responsible for the activity. Calythropsin was demonstrated to have a weak effect on mitosis, and presumably also on tubulin polymerization.[1]

References

  1. Two new cytotoxic chalcones from Calythropsis aurea. Beutler, J.A., Cardellina, J.H., Gray, G.N., Prather, T.R., Shoemaker, R.H., Boyd, M.R., Lin, C.M., Hamel, E., Cragg, G.M. J. Nat. Prod. (1993) [Pubmed]
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