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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Thomas, G.M. et al.

An essential role for phosphatidylinositol transfer protein in phospholipase C-mediated inositol lipid signaling.

Transmembrane signaling by the phospholipase C-beta (PLC-beta) pathway is known to require at least three components: the receptor, the G protein, and the PLC. Recent studies have indicated that if the cytosol is allowed to leak out of HL60 cells, then G protein- stimulated PLC activity is greatly diminished, indicating an essential role for a cytosolic component(s). We now report the complete purification of one component based on its ability to reconstitute GTP gamma S-mediated PLC activity and identify it as the phosphatidylinositol transfer protein (PI-TP). Based on the in vitro effects of PI-TP, we surmise that it is involved in transporting PI from intracellular compartments for conversion to PI bisphosphate (PIP2) prior to hydrolysis by PLC-beta 2/PLC-beta 3, the endogenous PLC isoforms present in these cells.[1]

References

An essential role for phosphatidylinositol transfer protein in phospholipase C-mediated inositol lipid signaling. Thomas, G.M., Cunningham, E., Fensome, A., Ball, A., Totty, N.F., Truong, O., Hsuan, J.J., Cockcroft, S. Cell (1993) [Pubmed]

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