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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death.

Apoptotic cell death is a mechanism by which organisms eliminate superfluous or harmful cells. Expression of the cell death regulatory protein REAPER ( RPR) in the developing Drosophila eye results in a small eye owing to excess cell death. We show that mutations in thread ( th) are dominant enhancers of RPR- induced cell death and that th encodes a protein homologous to baculovirus inhibitors of apoptosis (IAPs), which we call Drosophila IAP1 ( DIAP1). Overexpression of DIAP1 or a related protein, DIAP2, in the eye suppresses normally occurring cell death as well as death due to overexpression of rpr or head involution defective. IAP death-preventing activity localizes to the N-terminal baculovirus IAP repeats, a motif found in both viral and cellular proteins associated with death prevention.[1]

References

  1. Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Hay, B.A., Wassarman, D.A., Rubin, G.M. Cell (1995)
 
 
 
 
 
 
 
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