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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB.
Many cells are resistant to stimuli that can induce apoptosis, but the mechanisms involved are not fully understood. The activation of the transcription factor nuclear factor-kappa B (NF-kappaB) by tumor necrosis factor (TNF), ionizing radiation, or daunorubicin (a cancer chemotherapeutic compound), was found to protect from cell killing. Inhibition of NF-kappaB nuclear translocation enhanced apoptotic killing by these reagents but not by apoptotic stimuli that do not activate NF-kappaB. These results provide a mechanism of cellular resistance to killing by some apoptotic reagents, offer insight into a new role for NF-kappaB, and have potential for improvement of the efficacy of cancer therapies.[1]References
- TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Wang, C.Y., Mayo, M.W., Baldwin, A.S. Science (1996) [Pubmed]
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