- Physiologic estradiol replacement therapy and cardiac structure and function in normal postmenopausal women: a randomized, double-blind, placebo-controlled, crossover trial. Snabes, M.C., Payne, J.P., Kopelen, H.A., Dunn, J.K., Young, R.L., Zoghbi, W.A. Obstetrics and gynecology. (1997)