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Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex.
We have found that ectopic expression of cyclin A increases hormone-dependent and hormone-independent transcriptional activation by the estrogen receptor in vivo in a number of cell lines, including HeLa cells, U-2 OS osteosarcoma cells and Hs 578Bst breast epithelial cells. This effect can be further enhanced in HeLa cells by the concurrent expression of the cyclin-dependent kinase activator, cyclin H, and cdk7, and abolished by expression of the cdk inhibitor, p27(KIP1), or by the expression of a dominant negative catalytically inactive cdk2 mutant. ER is phosphorylated between amino acids 82 and 121 in vitro by the cyclin A/cdk2 complex and incorporation of phosphate into ER is stimulated by ectopic expression of cyclin A in vivo. Together, these results strongly suggest a direct role for the cyclin A/cdk2 complex in phosphorylating ER and regulating its transcriptional activity.[1]References
- Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex. Trowbridge, J.M., Rogatsky, I., Garabedian, M.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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