- Human Herpesvirus 7 induces CD4(+) T-cell death by two distinct mechanisms: necrotic lysis in productively infected cells and apoptosis in uninfected or nonproductively infected cells. Secchiero, P., Flamand, L., Gibellini, D., Falcieri, E., Robuffo, I., Capitani, S., Gallo, R.C., Zauli, G. Blood (1997)