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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Effects of an ionophore, X-537A, on mouse CNS cultures: a light and electron microscope study.

The effects of the ionophore X-537A on organotypic CNS tissue culture were investigated with bright field and electron microscopy. In addition to condensation of mitochondria this agent was found to induce a relatively selective vacuolation of the Golgi apparatus of neurons and glial cells. At the dosages used (50 mug/ml for 2-3 hours and 100 mug/ml for 1 hour) these changes were irreversible. Additional experiments suggested that the cellular effects of X-537A were primarily due to its ability to translocate Na+ across cellular membranes.[1]

References

  1. Effects of an ionophore, X-537A, on mouse CNS cultures: a light and electron microscope study. Tessler, A.R., Kim, S.U., Gonatas, N.K. J. Neuropathol. Exp. Neurol. (1976) [Pubmed]
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