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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 80 documents. Results 1 - 10.

Homo sapiens
Gene: ... protofilaments. High impact information on HAP1 All three of these proteins contain a short sequence, the heme...Disease relevance of HAP1 Nuclear localization of human AP endonuclease 1( HAP1/ Ref- 1) associates with prognosis in early operable non- small cell lung cancer( NSCLC). Human AP endonuclease 1( HAP1) protein... / Synonyms: HAP-1
HAP1  -  Hap1p
Saccharomyces cerevisiae S288c
Gene: ... High impact information on HAP1 While sequences between 445 and 1308 have no obvious function, a highly acidic carboxyl terminus mediates transcriptional activation by HAP1. We present the DNA sequence and a functional dissection of the 1483 residue yeast activator HAP1. The CYC1 and CYC7 sites compete for binding... / Synonyms: Heme-responsive zinc finger transcription factor HAP1
Rattus norvegicus
Gene: ... - 21- months- old, rats there is a downregulation of HAP1 mRNA expression across all CNS loci where HAP...Psychiatry related information on Hap1 The expression of Huntingtin- associated protein( HAP1) m... information on Hap1 The redox factor/ AP endonuclease Ref- 1( APE, APEX, HAP1) affects both DNA repair... / Synonyms: HAP-1; HAP1-A; HAP1-B
Mus musculus
Gene: ... Disease relevance of Hap1 Postnatally, Hap1 (-/-) pups show decreased feeding behavior that ultimately leads to malnutrition, dehydration and premature death. We have mapped its murine homolog, Hap1.... Decreasing the expression of mouse hypothalamic Hap1 by siRNA reduces the level and activity of hypothalamic... / Synonyms: HAP-1
Caenorhabditis elegans
Caenorhabditis remanei
MeSH term: ... not recovered, and mutations converting the direct repeat of CGGs to an inverted repeat greatly reduce HAP1... by the repetitive sequence. Moreover, substitution of the HAP1 dimerization domain with that of PPR1, which forms... information on Repetitive Sequences, Nucleic Acid Instead of an inverted repeat( CANNTG ), the target for all...
MeSH term: ... : neuronal selectivity and potential neuroprotective role of HAP1. Trains of spikes at 5- 20 Hz were used... on the neuroprotective mechanism of mGlu( 1) receptor antagonists. At young ages, all homozygous spa animals were spastic...
MeSH term: ... that Hap1 function is essential only for early postnatal feeding behavior. It is proposed... in the susceptibility to aberrant eating behaviors. Recently, it has been shown that targeted disruption of Hap1 in mice... fully suppresses all the phenotypic effects of held- up( 2 ), including the destructive hypercontraction...
Mus musculus
Gene: ... of Hdh The alteration of the huntingtin/ HAP1/ p150( Glued) complex correlates with reduced association... for neuronal dysfunction and degeneration due to mutant huntingtin. Loss of HAP- 1 expression did not alter...


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