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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 

Your search matched a total of 90 documents. Results 1 - 10.

Homo sapiens
Gene: ... Disease relevance of STAT4 Depressed IL- 12- mediated signal transduction in T cells from patients... of STAT4. Constitutive tyrosine and serine phosphorylation of STAT4 in T- cells transformed with HTLV- I. IL- 12- dependent constitutive STAT4 activation was also observed in the Epstein- Barr virus( EBV...
Mus musculus
Gene: ... Disease relevance of Stat4 Thus, Stat6 -/- and Stat4 -/- mice appeared to be resistant to septic... balancing cytokine responses. In Stat4 -/- mice, hepatic inflammation and injury during sepsis were significantly ameliorated without affecting local responses. Specifically, Stat4- deficient NZM mice develop...
Danio rerio
Gene: ... High impact information on stat4 There are seven mammalian signal transducer and activator of transcription( Stat) proteins that act downstream of cytokine and growth factor receptors to mediate rapid changes in gene expression....
MeSH term: ... explored the role of Stat4 and Stat6 in innate immunity during septic peritonitis. In the multivariate... of Peritonitis Thus, Stat6 -/- and Stat4 -/- mice appeared to be resistant to septic peritonitis by enhancing...
MeSH term: ... populations, Th1 and Th2 cells. Impaired IL- 12 responses and enhanced development of Th2 cells in Stat4... regulatory activity of cytokines that antagonize Th2 cells. Anatomical context of Th2 Cells Furthermore, Stat4- deficient lymphocytes demonstrate a propensity towards the development of Th2 cells. Immune...

 

 
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