Arie Zask
Chemical Sciences
Wyeth Research
Pearl River
NY 10965
USA
Name/email consistency: high
- Morpholine derivatives greatly enhance the selectivity of mammalian target of rapamycin (mTOR) inhibitors. Zask, A., Kaplan, J., Verheijen, J.C., Richard, D.J., Curran, K., Brooijmans, N., Bennett, E.M., Toral-Barza, L., Hollander, I., Ayral-Kaloustian, S., Yu, K. J. Med. Chem. (2009)
- ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. Zask, A., Verheijen, J.C., Curran, K., Kaplan, J., Richard, D.J., Nowak, P., Malwitz, D.J., Brooijmans, N., Bard, J., Svenson, K., Lucas, J., Toral-Barza, L., Zhang, W.G., Hollander, I., Gibbons, J.J., Abraham, R.T., Ayral-Kaloustian, S., Mansour, T.S., Yu, K. J. Med. Chem. (2009)
- Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. Zask, A., Kaplan, J., Toral-Barza, L., Hollander, I., Young, M., Tischler, M., Gaydos, C., Cinque, M., Lucas, J., Yu, K. J. Med. Chem. (2008)
- Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitors. Zask, A., Kaplan, J., Du, X., MacEwan, G., Sandanayaka, V., Eudy, N., Levin, J., Jin, G., Xu, J., Cummons, T., Barone, D., Ayral-Kaloustian, S., Skotnicki, J. Bioorg. Med. Chem. Lett. (2005)
- Hybrids of the hemiasterlin analogue taltobulin and the dolastatins are potent antimicrotubule agents. Zask, A., Kaplan, J., Musto, S., Loganzo, F. J. Am. Chem. Soc. (2005)
- D-piece modifications of the hemiasterlin analog HTI-286 produce potent tubulin inhibitors. Zask, A., Birnberg, G., Cheung, K., Kaplan, J., Niu, C., Norton, E., Yamashita, A., Beyer, C., Krishnamurthy, G., Greenberger, L.M., Loganzo, F., Ayral-Kaloustian, S. Bioorg. Med. Chem. Lett. (2004)
- Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286). Zask, A., Birnberg, G., Cheung, K., Kaplan, J., Niu, C., Norton, E., Suayan, R., Yamashita, A., Cole, D., Tang, Z., Krishnamurthy, G., Williamson, R., Khafizova, G., Musto, S., Hernandez, R., Annable, T., Yang, X., Discafani, C., Beyer, C., Greenberger, L.M., Loganzo, F., Ayral-Kaloustian, S. J. Med. Chem. (2004)
- Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors. Zask, A., Gu, Y., Albright, J.D., Du, X., Hogan, M., Levin, J.I., Chen, J.M., Killar, L.M., Sung, A., DiJoseph, J.F., Sharr, M.A., Roth, C.E., Skala, S., Jin, G., Cowling, R., Mohler, K.M., Barone, D., Black, R., March, C., Skotnicki, J.S. Bioorg. Med. Chem. Lett. (2003)
