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Dr Benoît Chénais

Professor

University of Maine

Le Mans

[email]@univ-lemans.fr

Name/email consistency: high

Benoît Chénais,

Affiliations

University of Maine, Le Mans, France - Lab "Sea, Molecules, Health" (Mer Molécules Santé); 2012-present
University of Maine, Le Mans, France - Molecular Biology & Evolutionary Genetics (head of the lab); 2005-2011
University of Reims-Champagne Ardennes, School of Pharmacy, Reims, France - Molecular Biology Lab (CNRS UMR MéDIAN); 2000-2004
Lady Davis Institute for medical research, Montréal, QC, Canada. 2002-2003
University of Reims-Champagne Ardennes, School of Pharmacy, Reims, France - Biochemistry & Molecular Biology Lab; 1994-2002
University Paris-XI, Orsay, France - Laboratory Bacterial Immunomodulators (CNRS URA 1116); 1990-1994

Regulation of gene expression

Nitric oxide synthesis and L-arginine metabolism in murine macrophages and microglial cells. Nitric oxide synthase (NOS) expression.
Globin and porphobilinogen deaminase in erythroid differentation of human leukemia induced by anthracyclines and butyric acid.
Transcription factors GATA-1 and NF-E2 in erythroid differentation of human leukemia induced by anthracyclines and butyric acid.
Matrix metalloproteinase (especially MMP-9) expression during HL-60 cells differentiation induced by anthracyclines and butyric acid.
Reactive oxygen species (ROS) involvement in human leukemia cell differentiation induced by anthracyclines and butyric acid.
Expression of the human NRF3 transcription factor.
Characterization and expression of stress response genes (HSP70, MnSOD, Metallothionein) in marine hydrothermal invertebrates (crabs).
Expression of stress-related genes (HSP70, Metallothionein, Catalase, Cu/ZnSOD, MnSOD, Cytochrome Oxydase-I, ABCB1) in marine organisms (cockles, fishes) exposed to environmental pollution (Cadmium, Mercury, Industrial effluents).
Characterization and functional study of transposable elements (especially mariner-like-element) in marine invertebrates (crabs), aphids and fruit fly.
Transcription factors of marine microalgae.
Rad51 DNA repair pathway.

References

Oxidative stress involvement in chemically induced differentiation of K562 cells. Chénais, B., Andriollo, M., Guiraud, P., Belhoussine, R., Jeannesson, P. Free Radic. Biol. Med. (2000) [Pubmed]
Inhibitory effect of nitric oxide on chemically induced differentiation of human leukemic K562 cells. Chénais, B., Molle, I., Jeannesson, P. Biochem. Pharmacol. (1999) [Pubmed]
Requirement of GATA-1 and p45 NF-E2 expression in butyric acid-induced erythroid differentiation. Chénais, B. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
Docosahexaenoic acid intake decreases proliferation, increases apoptosis and decreases the invasive potential of the human breast carcinoma cell line MDA-MB-231. Blanckaert, V., Ulmann, L., Mimouni, V., Antol, J., Brancquart, L., Chénais, B. Int. J. Oncol. (2010) [Pubmed]
Functional and placental expression analysis of the human NRF3 transcription factor. Chénais, B., Derjuga, A., Massrieh, W., Red-Horse, K., Bellingard, V., Fisher, S.J., Blank, V. Mol. Endocrinol. (2005) [Pubmed]
Impact of endogenous nitric oxide on microglial cell energy metabolism and labile iron pool. Chénais, B., Morjani, H., Drapier, J.C. J. Neurochem. (2002) [Pubmed]
DNA binding specificity and cleavage activity of Pacmmar transposase. Delaurière, L., Chénais, B., Pradier, E., Hardivillier, Y., Renault, S., Casse, N. Biochemistry. (2009) [Pubmed]
Involvement of reactive oxygen species in aclarubicin-induced differentiation and invasiveness of HL-60 leukemia cells. Richard, D., Hollender, P., Chénais, B. Int. J. Oncol. (2002) [Pubmed]
Butyric acid increases invasiveness of HL-60 leukemia cells: role of reactive oxygen species. Richard, D., Hollender, P., Chénais, B. FEBS. Lett. (2002) [Pubmed]
N omega-hydroxy-L-arginine, a reactional intermediate in nitric oxide biosynthesis, induces cytostasis in human and murine tumor cells. Chénais, B., Yapo, A., Lepoivre, M., Tenu, J.P. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
High-performance liquid chromatographic analysis of the unusual pathway of oxidation of L-arginine to citrulline and nitric oxide in mammalian cells. Chenais, B., Yapo, A., Lepoivre, M., Tenu, J.P. J. Chromatogr. (1991) [Pubmed]
Free radical production and labile iron pool decrease triggered by subtoxic concentration of aclarubicin in human leukemia cell lines. Richard, D., Morjani, H., Chénais, B. Leuk. Res. (2002) [Pubmed]

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