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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Dr Peter Huypens

Postdoctoral researcher

Helmholtz Zentrum München

Institute experimental genetics

Ingolstädter Landstraße 1

85764 Oberschleißheim



Name/email consistency: high



  • Diabetes Research Center, Brussels Free University - VUB, Laarbeeklaan 103, B-1090 Brussels, Belgium. 2007
  • V.U.B., Biochemistry, Laarbeeklaan 103, B-1090 Brussels, Belgium. 2007
  • Diabetes Research Center (Partner of the Juvenile Diabetes Research Center for Beta Cell Therapy in Europe), Brussels Free University - VUB, Brussels, Belgium. 2006



  1. Epigenetic germline inheritance of diet-induced obesity and insulin resistance. Huypens, P., Sass, S., Wu, M., Dyckhoff, D., Tschöp, M., Theis, F., Marschall, S., de Angelis, M.H., Beckers, J. Nat. Genet. (2016) [Pubmed]
  2. Metformin supports the antidiabetic effect of a sodium glucose cotransporter 2 inhibitor by suppressing endogenous glucose production in diabetic mice. Neschen, S., Scheerer, M., Seelig, A., Huypens, P., Schultheiss, J., Wu, M., Wurst, W., Rathkolb, B., Suhre, K., Wolf, E., Beckers, J., Hrabé de Angelis, M. Diabetes. (2015) [Pubmed]
  3. Overcoming the spatial barriers of the stimulus secretion cascade in pancreatic β-cells. Huypens, P.R., Huang, M., Joseph, J.W. Islets. (2012) [Pubmed]
  4. Adipokines regulate systemic insulin sensitivity in accordance to existing energy reserves. Huypens, P. Med. Hypotheses (2007) [Pubmed]
  5. Leptin and adiponectin regulate compensatory beta cell growth in accordance to overweight. Huypens, P.R. Med. Hypotheses (2007) [Pubmed]
  6. Leptin controls adiponectin production via the hypothalamus. Huypens, P. Med. Hypotheses (2007) [Pubmed]
  7. Adiponectin expression is paradoxically increased in gold-thioglucose-induced obesity. Huypens, P., Quartier, E. Horm. Metab. Res. (2006) [Pubmed]
  8. Aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor-1{beta} plays a critical role in maintaining glucose-stimulated anaplerosis and insulin release from pancreatic {beta}-cells. Pillai, R., Huypens, P., Huang, M., Schaefer, S., Sheinin, T., Wettig, S.D., Joseph, J.W. J. Biol. Chem. (2011) [Pubmed]
  9. The dicarboxylate carrier plays a role in mitochondrial malate transport and in the regulation of glucose-stimulated insulin secretion from rat pancreatic beta cells. Huypens, P., Pillai, R., Sheinin, T., Schaefer, S., Huang, M., Odegaard, M.L., Ronnebaum, S.M., Wettig, S.D., Joseph, J.W. Diabetologia. (2011) [Pubmed]
  10. Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states. Hasek, B.E., Stewart, L.K., Henagan, T.M., Boudreau, A., Lenard, N.R., Black, C., Shin, J., Huypens, P., Malloy, V.L., Plaisance, E.P., Krajcik, R.A., Orentreich, N., Gettys, T.W. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2010) [Pubmed]
  11. Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1. Chang, J.S., Huypens, P., Zhang, Y., Black, C., Kralli, A., Gettys, T.W. J. Biol. Chem. (2010) [Pubmed]
  12. Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha. Zhang, Y., Huypens, P., Adamson, A.W., Chang, J.S., Henagan, T.M., Boudreau, A., Lenard, N.R., Burk, D., Klein, J., Perwitz, N., Shin, J., Fasshauer, M., Kralli, A., Gettys, T.W. J. Biol. Chem. (2009) [Pubmed]
  13. Implications of crosstalk between leptin and insulin signaling during the development of diet-induced obesity. Morrison, C.D., Huypens, P., Stewart, L.K., Gettys, T.W. Biochim. Biophys. Acta. (2009) [Pubmed]
  14. Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase. Huypens, P., Quartier, E., Pipeleers, D., Van de Casteele, M. Eur. J. Pharmacol. (2005) [Pubmed]
  15. Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells. Huypens, P., Moens, K., Heimberg, H., Ling, Z., Pipeleers, D., Van de Casteele, M. Life. Sci. (2005) [Pubmed]
  16. Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Schuit, F.C., Huypens, P., Heimberg, H., Pipeleers, D.G. Diabetes. (2001) [Pubmed]
  17. Glucagon receptors on human islet cells contribute to glucose competence of insulin release. Huypens, P., Ling, Z., Pipeleers, D., Schuit, F. Diabetologia. (2000) [Pubmed]
  18. Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells. Moens, K., Heimberg, H., Flamez, D., Huypens, P., Quartier, E., Ling, Z., Pipeleers, D., Gremlich, S., Thorens, B., Schuit, F. Diabetes. (1996) [Pubmed]
  19. Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. De Vos, A., Heimberg, H., Quartier, E., Huypens, P., Bouwens, L., Pipeleers, D., Schuit, F. J. Clin. Invest. (1995) [Pubmed]
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