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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Charles H. Lang

Department of Cellular and Molecular Physiology

and Surgery

Pennsylvania State University College of Medicine

Hershey

USA

[email]@psu.edu

Name/email consistency: high

 
 
 
 
 
 
 

Affiliations

  • Department of Cellular and Molecular Physiology, and Surgery, Pennsylvania State University College of Medicine, Hershey, USA. 1998 - 2010
  • Pennsylvania State College of Medicine, Department of Cellular and Molecular Physiology (H166), Hershey, PA 17033, USA. 2004

References

  1. BCATm deficiency ameliorates endotoxin-induced decrease in muscle protein synthesis and improves survival in septic mice. Lang, C.H., Lynch, C.J., Vary, T.C. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2010) [Pubmed]
  2. Alcohol-induced IGF-I resistance is ameliorated in mice deficient for mitochondrial branched-chain aminotransferase. Lang, C.H., Lynch, C.J., Vary, T.C. J. Nutr. (2010) [Pubmed]
  3. Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine. Lang, C.H., Frost, R.A., Bronson, S.K., Lynch, C.J., Vary, T.C. Am. J. Physiol. Endocrinol. Metab. (2010) [Pubmed]
  4. Alcohol-induced decrease in muscle protein synthesis associated with increased binding of mTOR and raptor: Comparable effects in young and mature rats. Lang, C.H., Pruznak, A.M., Nystrom, G.J., Vary, T.C. Nutr. Metab. (Lond) (2009) [Pubmed]
  5. Acute alcohol intoxication increases REDD1 in skeletal muscle. Lang, C.H., Frost, R.A., Vary, T.C. Alcohol. Clin. Exp. Res. (2008) [Pubmed]
  6. Beta-adrenergic blockade exacerbates sepsis-induced changes in tumor necrosis factor alpha and interleukin-6 in skeletal muscle and is associated with impaired translation initiation. Lang, C.H., Nystrom, G., Frost, R.A. J. Trauma (2008) [Pubmed]
  7. Regulation of muscle protein synthesis during sepsis and inflammation. Lang, C.H., Frost, R.A., Vary, T.C. Am. J. Physiol. Endocrinol. Metab. (2007) [Pubmed]
  8. Skeletal muscle protein synthesis and degradation exhibit sexual dimorphism after chronic alcohol consumption but not acute intoxication. Lang, C.H., Frost, R.A., Vary, T.C. Am. J. Physiol. Endocrinol. Metab. (2007) [Pubmed]
  9. Burn-induced increase in atrogin-1 and MuRF-1 in skeletal muscle is glucocorticoid independent but downregulated by IGF-I. Lang, C.H., Huber, D., Frost, R.A. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2007) [Pubmed]
  10. Sepsis-induced suppression of skeletal muscle translation initiation mediated by tumor necrosis factor alpha. Lang, C.H., Frost, R.A. Metab. Clin. Exp. (2007) [Pubmed]
  11. Glucocorticoids and TNFalpha interact cooperatively to mediate sepsis-induced leucine resistance in skeletal muscle. Lang, C.H., Frost, R.A. Mol. Med. (2006) [Pubmed]
  12. Sepsis and inflammatory insults downregulate IGFBP-5, but not IGFBP-4, in skeletal muscle via a TNF-dependent mechanism. Lang, C.H., Krawiec, B.J., Huber, D., McCoy, J.M., Frost, R.A. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
  13. Elevated plasma free fatty acids decrease basal protein synthesis, but not the anabolic effect of leucine, in skeletal muscle. Lang, C.H. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  14. Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle. Lang, C.H., Frost, R.A. J. Cell. Physiol. (2005) [Pubmed]
  15. TNFalpha mediates sepsis-induced impairment of basal and leucine-stimulated signaling via S6K1 and eIF4E in cardiac muscle. Lang, C.H., Pruznak, A.M., Frost, R.A. J. Cell. Biochem. (2005) [Pubmed]
  16. Cytokine inhibition of JAK-STAT signaling: a new mechanism of growth hormone resistance. Lang, C.H., Hong-Brown, L., Frost, R.A. Pediatr. Nephrol. (2005) [Pubmed]
  17. Molecular mechanisms responsible for alcohol-induced myopathy in skeletal muscle and heart. Lang, C.H., Frost, R.A., Summer, A.D., Vary, T.C. Int. J. Biochem. Cell Biol. (2005) [Pubmed]
  18. Thermal injury impairs cardiac protein synthesis and is associated with alterations in translation initiation. Lang, C.H., Frost, R.A., Vary, T.C. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004) [Pubmed]
  19. IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats. Lang, C.H., Frost, R.A., Svanberg, E., Vary, T.C. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  20. Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiation. Lang, C.H., Frost, R.A. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  21. Leucine acutely reverses burn-induced alterations in translation initiation in heart. Lang, C.H., Deshpande, N., Frost, R.A. Shock (2004) [Pubmed]
  22. Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolism. Lang, C.H., Pruznak, A.M., Deshpande, N., Palopoli, M.M., Frost, R.A., Vary, T.C. Alcohol. Clin. Exp. Res. (2004) [Pubmed]
  23. Acute in vivo elevation of insulin-like growth factor (IGF) binding protein-1 decreases plasma free IGF-I and muscle protein synthesis. Lang, C.H., Vary, T.C., Frost, R.A. Endocrinology (2003) [Pubmed]
  24. Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle. Lang, C.H., Frost, R.A., Deshpande, N., Kumar, V., Vary, T.C., Jefferson, L.S., Kimball, S.R. Am. J. Physiol. Endocrinol. Metab. (2003) [Pubmed]
  25. Burn-induced changes in IGF-I and IGF-binding proteins are partially glucocorticoid dependent. Lang, C.H., Nystrom, G.J., Frost, R.A. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) [Pubmed]
  26. TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiation. Lang, C.H., Frost, R.A., Nairn, A.C., MacLean, D.A., Vary, T.C. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  27. Role of growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infection. Lang, C.H., Frost, R.A. Curr. Opin. Clin. Nutr. Metab. Care (2002) [Pubmed]
  28. Alcohol myopathy: impairment of protein synthesis and translation initiation. Lang, C.H., Kimball, S.R., Frost, R.A., Vary, T.C. Int. J. Biochem. Cell Biol. (2001) [Pubmed]
  29. Regulation of myostatin by glucocorticoids after thermal injury. Lang, C.H., Silvis, C., Nystrom, G., Frost, R.A. FASEB J. (2001) [Pubmed]
  30. Tissue-specific regulation of IGF-I and IGF-binding proteins in response to TNFalpha. Lang, C.H., Nystrom, G.J., Frost, R.A. Growth Horm. IGF Res. (2001) [Pubmed]
  31. Impaired protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4E in muscle and eIF2B in liver. Lang, C.H., Frost, R.A., Kumar, V., Wu, D., Vary, T.C. Alcohol. Clin. Exp. Res. (2000) [Pubmed]
  32. Acute response of IGF-I and IGF binding proteins induced by thermal injury. Lang, C.H., Liu, X., Nystrom, G.J., Frost, R.A. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]
  33. Endotoxin-induced decrease in muscle protein synthesis is associated with changes in eIF2B, eIF4E, and IGF-I. Lang, C.H., Frost, R.A., Jefferson, L.S., Kimball, S.R., Vary, T.C. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]
  34. Impaired myocardial protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4F. Lang, C.H., Frost, R.A., Kumar, V., Vary, T.C. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]
  35. Chronic alcohol feeding impairs hepatic translation initiation by modulating eIF2 and eIF4E. Lang, C.H., Wu, D., Frost, R.A., Jefferson, L.S., Vary, T.C., Kimball, S.R. Am. J. Physiol. (1999) [Pubmed]
  36. Role of central IL-1 in regulating peripheral IGF-I during endotoxemia and sepsis. Lang, C.H., Fan, J., Wojnar, M.M., Vary, T.C., Cooney, R. Am. J. Physiol. (1998) [Pubmed]
 
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