Andrew Fensome
Chemical and Screening Sciences
Biotransformation Division
Drug Safety and Metabolism
Women's Health and Musculoskeletal Biology
USA
Name/email consistency: high
- Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348). Fensome, A., Adams, W.R., Adams, A.L., Berrodin, T.J., Cohen, J., Huselton, C., Illenberger, A., Kern, J.C., Hudak, V.A., Marella, M.A., Melenski, E.G., McComas, C.C., Mugford, C.A., Slayden, O.D., Yudt, M., Zhang, Z., Zhang, P., Zhu, Y., Winneker, R.C., Wrobel, J.E. J. Med. Chem. (2008)
- Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal progesterone receptor agonist tanaproget. Fensome, A., Bender, R., Chopra, R., Cohen, J., Collins, M.A., Hudak, V., Malakian, K., Lockhead, S., Olland, A., Svenson, K., Terefenko, E.A., Unwalla, R.J., Wilhelm, J.M., Wolfrom, S., Zhu, Y., Zhang, Z., Zhang, P., Winneker, R.C., Wrobel, J. J. Med. Chem. (2005)
- Novel 5-aryl-1,3-dihydro-indole-2-thiones. potent, orally active progesterone receptor agonists. Fensome, A., Koko, M., Wrobel, J., Zhang, P., Zhang, Z., Cohen, J., Lundeen, S., Rudnick, K., Zhu, Y., Winneker, R. Bioorg. Med. Chem. Lett. (2003)
- New progesterone receptor antagonists: 3,3-disubstituted-5-aryloxindoles. Fensome, A., Bender, R., Cohen, J., Collins, M.A., Mackner, V.A., Miller, L.L., Ullrich, J.W., Winneker, R., Wrobel, J., Zhang, P., Zhang, Z., Zhu, Y. Bioorg. Med. Chem. Lett. (2002)
