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Galina I. Lepesheva

Department of Biochemistry

Vanderbilt University School of Medicine

Nashville

TN 37232-0146

USA

[email]@vanderbilt.edu

Name/email consistency: high

 
 
 
 
 
 
 

Affiliation

  • Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA. 2004 - 2010

References

  1. Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. Lepesheva, G.I., Park, H.W., Hargrove, T.Y., Vanhollebeke, B., Wawrzak, Z., Harp, J.M., Sundaramoorthy, M., Nes, W.D., Pays, E., Chaudhuri, M., Villalta, F., Waterman, M.R. J. Biol. Chem. (2010) [Pubmed]
  2. CYP51: A major drug target in the cytochrome P450 superfamily. Lepesheva, G.I., Hargrove, T.Y., Kleshchenko, Y., Nes, W.D., Villalta, F., Waterman, M.R. Lipids (2008) [Pubmed]
  3. Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth. Lepesheva, G.I., Ott, R.D., Hargrove, T.Y., Kleshchenko, Y.Y., Schuster, I., Nes, W.D., Hill, G.C., Villalta, F., Waterman, M.R. Chem. Biol. (2007) [Pubmed]
  4. CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase. Lepesheva, G.I., Zaitseva, N.G., Nes, W.D., Zhou, W., Arase, M., Liu, J., Hill, G.C., Waterman, M.R. J. Biol. Chem. (2006) [Pubmed]
  5. Biodiversity of CYP51 in trypanosomes. Lepesheva, G.I., Hargrove, T.Y., Ott, R.D., Nes, W.D., Waterman, M.R. Biochem. Soc. Trans. (2006) [Pubmed]
  6. CYP51 from Trypanosoma brucei is obtusifoliol-specific. Lepesheva, G.I., Nes, W.D., Zhou, W., Hill, G.C., Waterman, M.R. Biochemistry (2004) [Pubmed]
 
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