Galina I. Lepesheva
Department of Biochemistry
Vanderbilt University School of Medicine
Nashville
TN 37232-0146
USA
Name/email consistency: high
- Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. Lepesheva, G.I., Park, H.W., Hargrove, T.Y., Vanhollebeke, B., Wawrzak, Z., Harp, J.M., Sundaramoorthy, M., Nes, W.D., Pays, E., Chaudhuri, M., Villalta, F., Waterman, M.R. J. Biol. Chem. (2010)
- CYP51: A major drug target in the cytochrome P450 superfamily. Lepesheva, G.I., Hargrove, T.Y., Kleshchenko, Y., Nes, W.D., Villalta, F., Waterman, M.R. Lipids (2008)
- Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth. Lepesheva, G.I., Ott, R.D., Hargrove, T.Y., Kleshchenko, Y.Y., Schuster, I., Nes, W.D., Hill, G.C., Villalta, F., Waterman, M.R. Chem. Biol. (2007)
- CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase. Lepesheva, G.I., Zaitseva, N.G., Nes, W.D., Zhou, W., Arase, M., Liu, J., Hill, G.C., Waterman, M.R. J. Biol. Chem. (2006)
- Biodiversity of CYP51 in trypanosomes. Lepesheva, G.I., Hargrove, T.Y., Ott, R.D., Nes, W.D., Waterman, M.R. Biochem. Soc. Trans. (2006)
- CYP51 from Trypanosoma brucei is obtusifoliol-specific. Lepesheva, G.I., Nes, W.D., Zhou, W., Hill, G.C., Waterman, M.R. Biochemistry (2004)









