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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Gary L. Grunewald

Department of Medicinal Chemistry

The University of Kansas

Lawrence

KS 66045

USA

[email]@ku.edu

Name/email consistency: high

 
 
 
 
 
 
 

Affiliation

  • Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045, USA. 2005 - 2008

References

  1. Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase. Grunewald, G.L., Seim, M.R., Bhat, S.R., Wilson, M.E., Criscione, K.R. Bioorg. Med. Chem. (2008) [Pubmed]
  2. Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors. Grunewald, G.L., Seim, M.R., Regier, R.C., Criscione, K.R. Bioorg. Med. Chem. (2007) [Pubmed]
  3. Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluorination. Grunewald, G.L., Seim, M.R., Lu, J., Makboul, M., Criscione, K.R. J. Med. Chem. (2006) [Pubmed]
  4. Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase. Grunewald, G.L., Seim, M.R., Regier, R.C., Martin, J.L., Gee, C.L., Drinkwater, N., Criscione, K.R. J. Med. Chem. (2006) [Pubmed]
  5. 3-hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display remarkable potency and selectivity. Grunewald, G.L., Romero, F.A., Criscione, K.R. J. Med. Chem. (2005) [Pubmed]
  6. Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines. Grunewald, G.L., Romero, F.A., Seim, M.R., Criscione, K.R., Deupree, J.D., Spackman, C.C., Bylund, D.B. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  7. Nanomolar inhibitors of CNS epinephrine biosynthesis: (R)-(+)-3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines as potent and highly selective inhibitors of phenylethanolamine N-methyltransferase1. Grunewald, G.L., Romero, F.A., Criscione, K.R. J. Med. Chem. (2005) [Pubmed]
  8. Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity. Grunewald, G.L., Lu, J., Criscione, K.R., Okoro, C.O. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
 
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