Ian R. Hardcastle
Northern Institute for Cancer Research University of Newcastle upon Tyne
Newcastle upon Tyne
NE1 4RU
United Kingdom
Name/email consistency: high
- Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold. Hardcastle, I.R., Ahmed, S.U., Atkins, H., Farnie, G., Golding, B.T., Griffin, R.J., Guyenne, S., Hutton, C., Källblad, P., Kemp, S.J., Kitching, M.S., Newell, D.R., Norbedo, S., Northen, J.S., Reid, R.J., Saravanan, K., Willems, H.M., Lunec, J. J. Med. Chem. (2006)
- Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction. Hardcastle, I.R., Ahmed, S.U., Atkins, H., Calvert, A.H., Curtin, N.J., Farnie, G., Golding, B.T., Griffin, R.J., Guyenne, S., Hutton, C., Källblad, P., Kemp, S.J., Kitching, M.S., Newell, D.R., Norbedo, S., Northen, J.S., Reid, R.J., Saravanan, K., Willems, H.M., Lunec, J. Bioorg. Med. Chem. Lett. (2005)
- Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. Hardcastle, I.R., Cockcroft, X., Curtin, N.J., El-Murr, M.D., Leahy, J.J., Stockley, M., Golding, B.T., Rigoreau, L., Richardson, C., Smith, G.C., Griffin, R.J. J. Med. Chem. (2005)
- N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2. Hardcastle, I.R., Arris, C.E., Bentley, J., Boyle, F.T., Chen, Y., Curtin, N.J., Endicott, J.A., Gibson, A.E., Golding, B.T., Griffin, R.J., Jewsbury, P., Menyerol, J., Mesguiche, V., Newell, D.R., Noble, M.E., Pratt, D.J., Wang, L.Z., Whitfield, H.J. J. Med. Chem. (2004)
- Designing inhibitors of cyclin-dependent kinases. Hardcastle, I.R., Golding, B.T., Griffin, R.J. Annu. Rev. Pharmacol. Toxicol. (2002)









