Tomoshige Kino
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health
Bethesda
MD 20892
USA
Name/email consistency: high
- ZNF764 haploinsufficiency may explain partial glucocorticoid, androgen, and thyroid hormone resistance associated with 16p11.2 microdeletion. Kino, T., Pavlatou, M.G., Moraitis, A.G., Nemery, R.L., Raygada, M., Stratakis, C.A. J. Clin. Endocrinol. Metab. (2012)
- Glucocorticoid receptor: implications for rheumatic diseases. Kino, T., Charmandari, E., Chrousos, G.P. Clin. Exp. Rheumatol. (2011)
- Acetylation-mediated epigenetic regulation of glucocorticoid receptor activity: circadian rhythm-associated alterations of glucocorticoid actions in target tissues. Kino, T., Chrousos, G.P. Mol. Cell. Endocrinol. (2011)
- Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor. Kino, T., Hurt, D.E., Ichijo, T., Nader, N., Chrousos, G.P. Sci. Signal (2010)
- Cyclin-dependent kinase 5 modulates the transcriptional activity of the mineralocorticoid receptor and regulates expression of brain-derived neurotrophic factor. Kino, T., Jaffe, H., Amin, N.D., Chakrabarti, M., Zheng, Y.L., Chrousos, G.P., Pant, H.C. Mol. Endocrinol. (2010)
- Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5. Kino, T., Takatori, H., Manoli, I., Wang, Y., Tiulpakov, A., Blackman, M.R., Su, Y.A., Chrousos, G.P., DeCherney, A.H., Segars, J.H. Sci. Signal (2009)
- Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity. Kino, T., Manoli, I., Kelkar, S., Wang, Y., Su, Y.A., Chrousos, G.P. Biochem. Biophys. Res. Commun. (2009)
- Human glucocorticoid receptor isoform beta: recent understanding of its potential implications in physiology and pathophysiology. Kino, T., Su, Y.A., Chrousos, G.P. Cell. Mol. Life Sci. (2009)
- Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress. Kino, T., Ichijo, T., Amin, N.D., Kesavapany, S., Wang, Y., Kim, N., Rao, S., Player, A., Zheng, Y.L., Garabedian, M.J., Kawasaki, E., Pant, H.C., Chrousos, G.P. Mol. Endocrinol. (2007)
- 3-O-Formyl-20R,21-epoxyresibufogenin suppresses IL-6-type cytokine actions by targeting the glycoprotein 130 subunit: potential clinical implications. Kino, T., Boos, T.L., Sulima, A., Siegel, E.M., Gold, P.W., Rice, K.C., Chrousos, G.P. J. Allergy Clin. Immunol. (2007)
- Virus-mediated modulation of the host endocrine signaling systems: clinical implications. Kino, T., Chrousos, G.P. Trends Endocrinol. Metab. (2007)
- Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system. Kino, T., Souvatzoglou, E., Charmandari, E., Ichijo, T., Driggers, P., Mayers, C., Alatsatianos, A., Manoli, I., Westphal, H., Chrousos, G.P., Segars, J.H. J. Biol. Chem. (2006)
- HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected patients. Kino, T., De Martino, M.U., Charmandari, E., Ichijo, T., Outas, T., Chrousos, G.P. Diabetes (2005)
- G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus. Kino, T., Tiulpakov, A., Ichijo, T., Chheng, L., Kozasa, T., Chrousos, G.P. J. Cell Biol. (2005)
- Statin-induced blockade of prenylation alters nucleocytoplasmic shuttling of GTP-binding proteins gamma2 and beta2 and enhances their suppressive effect on glucocorticoid receptor transcriptional activity. Kino, T., Kozasa, T., Chrousos, G.P. Eur. J. Clin. Invest. (2005)
- Glucocorticoid and mineralocorticoid receptors and associated diseases. Kino, T., Chrousos, G.P. Essays Biochem. (2004)
- Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?. Kino, T., Chrousos, G.P. Ann. N. Y. Acad. Sci. (2004)
- FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors. Kino, T., Ichijo, T., Chrousos, G.P. J. Steroid Biochem. Mol. Biol. (2004)
- Glucocorticoid receptor mutants demonstrate increased motility inside the nucleus of living cells: time of fluorescence recovery after photobleaching (FRAP) is an integrated measure of receptor function. Kino, T., Liou, S.H., Charmandari, E., Chrousos, G.P. Mol. Med. (2004)
- Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators. Kino, T., Chrousos, G.P. J. Biol. Chem. (2003)
- Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway. Kino, T., Souvatzoglou, E., De Martino, M.U., Tsopanomihalu, M., Wan, Y., Chrousos, G.P. J. Biol. Chem. (2003)
- AIDS-related lipodystrophy/insulin resistance syndrome. Kino, T., Mirani, M., Alesci, S., Chrousos, G.P. Horm. Metab. Res. (2003)
- AIDS-related insulin resistance and lipodystrophy syndrome. Kino, T., Chrousos, G.P. Curr. Drug Targets Immune Endocr. Metabol. Disord. (2003)
- Tissue glucocorticoid resistance/hypersensitivity syndromes. Kino, T., De Martino, M.U., Charmandari, E., Mirani, M., Chrousos, G.P. J. Steroid Biochem. Mol. Biol. (2003)
- Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex. Kino, T., Slobodskaya, O., Pavlakis, G.N., Chrousos, G.P. J. Biol. Chem. (2002)
- Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators. Kino, T., Gragerov, A., Slobodskaya, O., Tsopanomichalou, M., Chrousos, G.P., Pavlakis, G.N. J. Virol. (2002)
- Transcription factor TFIIH components enhance the GR coactivator activity but not the cell cycle-arresting activity of the human immunodeficiency virus type-1 protein Vpr. Kino, T., Tsukamoto, M., Chrousos, G. Biochem. Biophys. Res. Commun. (2002)
- Familial/sporadic glucocorticoid resistance syndrome and hypertension. Kino, T., Vottero, A., Charmandari, E., Chrousos, G.P. Ann. N. Y. Acad. Sci. (2002)
- Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking. Kino, T., Stauber, R.H., Resau, J.H., Pavlakis, G.N., Chrousos, G.P. J. Clin. Endocrinol. Metab. (2001)
- Glucocorticoids suppress human immunodeficiency virus type-1 long terminal repeat activity in a cell type-specific, glucocorticoid receptor-mediated fashion: direct protective effects at variance with clinical phenomenology. Kino, T., Kopp, J.B., Chrousos, G.P. J. Steroid Biochem. Mol. Biol. (2000)
- Conditional modulation of glucocorticoid receptor activities by CREB-binding protein (CBP) and p300. Kino, T., Nordeen, S.K., Chrousos, G.P. J. Steroid Biochem. Mol. Biol. (1999)
