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Osmond J. D'Cruz

Parker Hughes Institute

St Paul

MN 55113

USA

[email]@ih.org

Name/email consistency: high

 
 
 
 
 
 
 

Affiliations

  • Parker Hughes Institute, St Paul, MN 55113, USA. 2005 - 2007
  • Drug Discovery Program, Paradigm Pharmaceuticals, LLC, Patton Road, St. Paul, USA. 1999 - 2007
  • Department of Reproductive Biology, Wayne Hughes Institute, Roseville, Minnesota 55113, USA. 1998 - 2005
  • Drug Discovery Program, Parker Hughes Cancer Center, Parker Hughes Institute, 2699 Patton Road, USA. 2002 - 2005
  • Drug Discovery Program, Departments of Reproductive Biology, Chemistry, and. Virology, USA. 2000 - 2004
  • Drug Discovery Program, Department of Reproductive Biology, Parker Hughes Institute and Paradigm Pharmaceuticals, LLC, St Paul, USA. 2003

References

  1. Limitations of the human-PBL-SCID mouse model for vaginal transmission of HIV-1. D'Cruz, O.J., Uckun, F.M. Am. J. Reprod. Immunol. (2007) [Pubmed]
  2. Mucosal safety of PHI-443 and stampidine as a combination microbicide to prevent genital transmission of HIV-1. D'Cruz, O.J., Uckun, F.M. Fertil. Steril. (2007) [Pubmed]
  3. Preclinical evaluation of a dual-acting microbicidal prodrug WHI-07 in combination with vanadocene dithiocarbamate in the female reproductive tract of rabbit, pig, and cat. D'Cruz, O.J., Uckun, F.M. Toxicol. Pathol (2007) [Pubmed]
  4. Dawn of non-nucleoside inhibitor-based anti-HIV microbicides. D'Cruz, O.J., Uckun, F.M. J. Antimicrob. Chemother. (2006) [Pubmed]
  5. Novel broad-spectrum thiourea non-nucleoside inhibitors for the prevention of mucosal HIV transmission. D'Cruz, O.J., Uckun, F.M. Curr. HIV Res. (2006) [Pubmed]
  6. Influence of long-term stability conditions on microbicidal nucleoside prodrug (WHI-07)-loaded gel-microemulsion. D'Cruz, O.J., Uckun, F.M. AAPS. PharmSciTech (2006) [Pubmed]
  7. Novel tight binding PETT, HEPT and DABO-based non-nucleoside inhibitors of HIV-1 reverse transcriptase. D'Cruz, O.J., Uckun, F.M. J. Enzyme. Inhib. Med. Chem (2006) [Pubmed]
  8. Stampidine: a selective oculo-genital microbicide. D'Cruz, O.J., Uckun, F.M. J. Antimicrob. Chemother. (2005) [Pubmed]
  9. Vaginal contraceptive activity of a chelated vanadocene. D'Cruz, O.J., Uckun, F.M. Contraception (2005) [Pubmed]
  10. A study of the potential of the pig as a model for the vaginal irritancy of benzalkonium chloride in comparison to the nonirritant microbicide PHI-443 and the spermicide vanadocene dithiocarbamate. D'Cruz, O.J., Erbeck, D., Uckun, F.M. Toxicol. Pathol (2005) [Pubmed]
  11. Discovery of 2,5-dimethoxy-substituted 5-bromopyridyl thiourea (PHI-236) as a potent broad-spectrum anti-human immunodeficiency virus microbicide. D'Cruz, O.J., Uckun, F.M. Mol. Hum. Reprod. (2005) [Pubmed]
  12. Conceival, a novel noncontraceptive vaginal vehicle for lipophilic microbicides. D'Cruz, O.J., Samuel, P., Uckun, F.M. AAPS. PharmSciTech (2005) [Pubmed]
  13. Clinical development of microbicides for the prevention of HIV infection. D'Cruz, O.J., Uckun, F.M. Curr. Pharm. Des. (2004) [Pubmed]
  14. Stampidine is a potential nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide. D'Cruz, O.J., Uckun, F.M. Fertil. Steril. (2004) [Pubmed]
  15. Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats. D'Cruz, O.J., Waurzyniak, B., Uckun, F.M. Antimicrob. Agents Chemother. (2004) [Pubmed]
  16. A 13-week subchronic intravaginal toxicity study of pokeweed antiviral protein in mice. D'Cruz, O.J., Waurzyniakt, B., Uckun, F.M. Phytomedicine (2004) [Pubmed]
  17. Mucosal toxicity studies of a gel formulation of native pokeweed antiviral protein. D'Cruz, O.J., Waurzyniak, B., Uckun, F.M. Toxicol. Pathol (2004) [Pubmed]
  18. PHI-443: a novel noncontraceptive broad-spectrum anti-human immunodeficiency virus microbicide. D'Cruz, O.J., Samuel, P., Uckun, F.M. Biol. Reprod. (2004) [Pubmed]
  19. Potent dual anti-HIV and spermicidal activities of novel oxovanadium(V) complexes with thiourea non-nucleoside inhibitors of HIV-1 reverse transcriptase. D'Cruz, O.J., Dong, Y., Uckun, F.M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  20. Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07) in rabbits. D'Cruz, O.J., Uckun, F.M. Fertil. Steril. (2003) [Pubmed]
  21. Development and evaluation of a thermoreversible ovule formulation of stampidine, a novel nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide. D'Cruz, O.J., Samuel, P., Waurzyniak, B., Uckun, F.M. Biol. Reprod. (2003) [Pubmed]
  22. Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-05) in rabbits. D'Cruz, O.J., Uckun, F.M. Arzneimittelforschung (2003) [Pubmed]
  23. Developmental toxicology studies of WHI-07, a novel nucleoside analogue-based dual-function microbicide, administered intravaginally to rabbits. D'Cruz, O.J., Erbeck, D., Uckun, F.M. Toxicol. Pathol (2003) [Pubmed]
  24. Subchronic (13-week) toxicity studies of intravaginal administration of spermicidal vanadocene acetylacetonato monotriflate in mice. D'Cruz, O.J., Waurzyniak, B., Uckun, F.M. Toxicology (2002) [Pubmed]
  25. Two-year toxicity and carcinogenicity studies in B(6)C(3)F(1) mice with 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent. D'Cruz, O.J., Erbeck, D., Waurzyniak, B., Uckun, F.M. Toxicology (2002) [Pubmed]
  26. Structural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitors of HIV-1 reverse transcriptase. D'Cruz, O.J., Venkatachalam, T.K., Mao, C., Qazi, S., Uckun, F.M. Biol. Reprod. (2002) [Pubmed]
  27. Metvan: a novel oxovanadium(IV) complex with broad spectrum anticancer activity. D'Cruz, O.J., Uckun, F.M. Expert. Opin. Investig. Drugs (2002) [Pubmed]
  28. Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07). D'Cruz, O.J., Uckun, F.M. J. Antimicrob. Chemother. (2002) [Pubmed]
  29. A 13-week subchronic intravaginal toxicity study of the novel broad-spectrum anti-HIV and spermicidal agent, N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (PHI-346) in mice. D'Cruz, O.J., Waurzyniak, B., Uckun, F.M. Toxicol. Pathol (2002) [Pubmed]
  30. Thymidine kinase-independent intracellular delivery of bioactive nucleotides by aryl phosphate derivatives of bromo-methoxy zidovudine (compounds WHI-05 and WHI-07) in normal human female genital tract epithelial cells and sperm. D'Cruz, O.J., Venkatachalam, T.K., Uckun, F.M. Biol. Reprod. (2001) [Pubmed]
  31. Pokeweed antiviral protein: a potential nonspermicidal prophylactic antiviral agent. D'Cruz, O.J., Uckun, F.M. Fertil. Steril. (2001) [Pubmed]
  32. Contraceptive efficacy and safety studies of a novel microemulsion-based lipophilic vaginal spermicide. D'Cruz, O.J., Yiv, S.H., Waurzyniak, B., Uckun, F.M. Fertil. Steril. (2001) [Pubmed]
  33. Short-Term (13-week) toxicity study of 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent, in B6C3F1 mice. D'Cruz, O.J., Uckun, F.M. Toxicol. Sci. (2001) [Pubmed]
  34. Members of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway are present and active in human sperm. D'Cruz, O.J., Vassilev, A.O., Uckun, F.M. Fertil. Steril. (2001) [Pubmed]
  35. Lack of adverse effects on fertility of female CD-1 mice exposed to repetitive intravaginal gel-microemulsion formulation of a dual-function anti-HIV agent: aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07). D'Cruz, O.J., Uckun, F.M. J. Appl. Toxicol (2001) [Pubmed]
  36. Bis(4,7-dimethyl and 5-dinitro-1,10-phenanthroline) sulfato-oxovanadium(IV)-mediated in vivo male germ cell apoptosis. D'Cruz, O.J., Uckun, F.M. J. Appl. Toxicol (2001) [Pubmed]
  37. Effect of pretreatment of semen with pokeweed antiviral protein on pregnancy outcome in the rabbit model. D'Cruz, O.J., Uckun, F.M. Fertil. Steril. (2001) [Pubmed]
  38. Gel-microemulsions as vaginal spermicides and intravaginal drug delivery vehicles. D'Cruz, O.J., Uckun, F.M. Contraception (2001) [Pubmed]
  39. Subchronic (13-week) toxicity studies of intravaginal administration of spermicidal vanadocene dithiocarbamate in mice. D'Cruz, O.J., Waurzyniak, B., Uckun, F.M. Contraception (2001) [Pubmed]
  40. GM-144, a novel lipophilic vaginal contraceptive gel-microemulsion. D'Cruz, O.J., Yiv, S.H., Uckun, F.M. AAPS. PharmSciTech (2001) [Pubmed]
  41. Structural requirements for potent human spermicidal activity of dual-function aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07). D'Cruz, O.J., Venkatachalam, T.K., Uckun, F.M. Biol. Reprod. (2000) [Pubmed]
  42. Studies in humans on the mechanism of potent spermicidal and apoptosis-inducing activities of vanadocene complexes. D'Cruz, O.J., Vassilev, A., Uckun, F.M. Biol. Reprod. (2000) [Pubmed]
  43. Evaluation of subchronic (13 weeks) and reproductive toxicity potential of intravaginal gel-microemulsion formulation of a dual-function phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-05) in B(6)C(3)F(1) mice. D'Cruz, O.J., Waurzyniak, B., Yiv, S.H., Uckun, F.M. Contraception (2000) [Pubmed]
  44. Evaluation of boar sperm as a model system to study the mechanism of spermicidal activity of vanadocenes. D'Cruz, O.J., Vassilev, A., Uckun, F.M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  45. Vanadocene-mediated in vivo male germ cell apoptosis. D'Cruz, O.J., Uckun, F.M. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
  46. Evaluation of subchronic (13-week) and reproductive toxicity potential of intravaginal gel-microemulsion formulation of a dual-function phenyl phosphate derivative of bromo-methoxy zidovudine (compound whi-07) in B(6)C(3)F(1) mice. D'Cruz, O.J., Waurzyniak, B., Yiv, S.H., Uckun, F.M. J. Appl. Toxicol (2000) [Pubmed]
  47. WHI-05, a novel bromo-methoxy substituted phenyl phosphate derivative of zidovudine, is a dual-action spermicide with potent anti-HIV activity. D'Cruz, O.J., Zhu, Z., Yiv, S.H., Chen, C.L., Waurzyniak, B., Uckun, F.M. Contraception (1999) [Pubmed]
  48. Spermicidal activity of oxovanadium(IV) complexes of 1, 10-phenanthroline, 2,2'-bipyridyl, 5'-bromo-2'-hydroxyacetophenone and derivatives in humans. D'Cruz, O.J., Dong, Y., Uckun, F.M. Biol. Reprod. (1999) [Pubmed]
  49. Spermicidal activity of metallocene complexes containing vanadium(IV) in humans. D'Cruz, O.J., Ghosh, P., Uckun, F.M. Biol. Reprod. (1998) [Pubmed]
 
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