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R. Scott Obach

Pfizer Inc. Groton

CT 06340

USA

[email]@pfizer.com

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Affiliations

Pfizer Inc. Groton, CT 06340, USA. 2009 - 2011
Pharmacokinetics, Dynamics and Metabolism Department, Pfizer Global Research and Development, Groton, USA. 2008
Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Pfizer, USA. 2005 - 2008
Pfizer Global Research and Development, Groton Laboratories, MS4088, Groton, USA. 2006

References

Addressing MIST (Metabolites in Safety Testing): Bioanalytical Approaches to Address Metabolite Exposures in Humans and Animals. Gao, H., Obach, R.S. Curr. Drug Metab. (2011) [Pubmed]
Metabolism of ramelteon in human liver microsomes and correlation with the effect of fluvoxamine on ramelteon pharmacokinetics. Obach, R.S., Ryder, T.F. Drug Metab. Dispos. (2010) [Pubmed]
Glycerolysis of acyl glucuronides as an artifact of in vitro drug metabolism incubations. Obach, R.S. Drug Metab. Dispos. (2009) [Pubmed]
Predicting drug-drug interactions from in vitro drug metabolism data: challenges and recent advances. Obach, R.S. Curr. Opin. Drug. Discov. Devel (2009) [Pubmed]
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose. Obach, R.S., Kalgutkar, A.S., Soglia, J.R., Zhao, S.X. Chem. Res. Toxicol. (2008) [Pubmed]
In vitro metabolism and covalent binding of enol-carboxamide derivatives and anti-inflammatory agents sudoxicam and meloxicam: insights into the hepatotoxicity of sudoxicam. Obach, R.S., Kalgutkar, A.S., Ryder, T.F., Walker, G.S. Chem. Res. Toxicol. (2008) [Pubmed]
Comparison of metabolite profiles generated in Aroclor-induced rat liver and human liver subcellular fractions: considerations for in vitro genotoxicity hazard assessment. Obach, R.S., Dobo, K.L. Environ. Mol. Mutagen. (2008) [Pubmed]
In vitro metabolism of CP-122,721 ((2S,3S)-2-phenyl-3-[(5-trifluoromethoxy-2-methoxy)benzylamino]piperidine), a non-peptide antagonist of the substance P receptor. Obach, R.S., Margolis, J.M., Logman, M.J. Drug Metab. Pharmacokinet. (2007) [Pubmed]
Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions. Obach, R.S., Walsky, R.L., Venkatakrishnan, K. Drug Metab. Dispos. (2007) [Pubmed]
The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions. Obach, R.S., Walsky, R.L., Venkatakrishnan, K., Gaman, E.A., Houston, J.B., Tremaine, L.M. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
Metabolism and disposition of varenicline, a selective alpha4beta2 acetylcholine receptor partial agonist, in vivo and in vitro. Obach, R.S., Reed-Hagen, A.E., Krueger, S.S., Obach, B.J., O'Connell, T.N., Zandi, K.S., Miller, S., Coe, J.W. Drug Metab. Dispos. (2006) [Pubmed]
Metabolism of nomifensine to a dihydroisoquinolinium ion metabolite by human myeloperoxidase, hemoglobin, monoamine oxidase A, and cytochrome P450 enzymes. Obach, R.S., Dalvie, D.K. Drug Metab. Dispos. (2006) [Pubmed]
Drugs that inhibit oxidation reactions catalyzed by aldehyde oxidase do not inhibit the reductive metabolism of ziprasidone to its major metabolite, S-methyldihydroziprasidone: an in vitro study. Obach, R.S., Walsky, R.L. J. Clin. Psychopharmacol (2005) [Pubmed]