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Chemical Compound Review:

Phloretate 3-(4-hydroxyphenyl)propanoic acid

Synonyms: HPPA, Phloretinate, Phloretic acid, uHLORETIC ACID, SureCN35486, ...

Kusu, F. et al., Zhu, Q.Z. et al., Sasaki, M. et al., Takei, K. et al., Ekman, R. et al., et al.

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Disease relevance of uHLORETIC ACID

Peptostreptococcus anaerobius was found to metabolize tyrosine to p-hydroxyhydrocinnamic acid [3-(p-hydroxyphenyl)propionic acid] [1].
3-(p-hydroxyphenyl)Propionic acid underwent net secretion under conditions of polyuria and high urinary pH and net reabsorption under conditions of oliguria and low pH [2].

High impact information on uHLORETIC ACID

The detection scheme is based on the peroxidase catalysed dimerization of 4-hydroxyphenylpropionic acid (pHPPA) and the subsequent formation of a ternary complex with Tb(III)EDTA [3].
After changing the temperature to separate the PNIP-antibody-HBsAg-antibody-FeTSPc conjugate moiety, it was re-dissolved and determined by coupling with the fluorogenic reaction of hydrogen peroxide and p-hydroxyphenylpropionic acid [4].
A simple, sensitive fluorometric assay system was developed for measuring H2O2 in the superfusate of macrophages after stimulation by use of immobilized peroxidase and 3-(p-hydroxyphenyl)propionic acid as a fluorogenic substrate [5].
A p-hydroxyphenylpropionic acid conjugate of DSIP was used for radioiodination [6].
We explored the regulation of enzyme-substrate (ES) complexation using horseradish peroxidase (HRP) as the enzyme and 4-aminoantipyrine (AAP) and 3-(p-hydroxyphenyl) propionic acid (HPPA) as substrates [7].

Associations of uHLORETIC ACID with other chemical compounds

Peroxidase activity bound to the polystyrene ball was assayed by fluorometry using 3-(4-hydroxyphenyl)propionic acid as the hydrogen donor [8].

Gene context of uHLORETIC ACID

A fluorometric assay using 3-(p-hydroxyphenyl) propionic acid (HPPA) was conducted to determine the activity of pseudocholinesterase (ChE) [Enzyme Commission (EC) No. 3.1.1.8] in postmortem blood samples so as to test for organophosphate poisoning [9].

Analytical, diagnostic and therapeutic context of uHLORETIC ACID

Radioimmunoassay of delta sleep-inducing peptide using an iodinated p-hydroxyphenylpropionic acid derivative as tracer [6].
Bound peroxidase activity was measured by fluorimetry using 3-(4-hydroxyphenyl)propionic acid as a substrate [10].

References

Production of p-hydroxyhydrocinnamic acid from tyrosine by Peptostreptococcus anaerobius. Lambert, M.A., Moss, C.W. J. Clin. Microbiol. (1980) [Pubmed]
Structural specificity in the renal tubular transport of tyrosine. Williams, W.M., Huang, K.C. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
Enzyme-linked immunosorbent assays based on peroxidase labels and enzyme-amplified lanthanide luminescence detection. Meyer, J., Karst, U. The Analyst. (2001) [Pubmed]
A novel mimetic enzymatic fluorescence immunoassay for hepatitis B surface antigen by using a thermal phase separating polymer. Zhu, Q.Z., Yang, H.H., Li, D.H., Chen, Q.Y., Xu, J.G. The Analyst. (2000) [Pubmed]
Intracellular Ca2+ concentration and H2O2 production in mouse peritoneal macrophages are stimulated by platelet activating factor. Sasaki, M., Maeyama, K., Watanabe, T. Lipids (1991) [Pubmed]
Radioimmunoassay of delta sleep-inducing peptide using an iodinated p-hydroxyphenylpropionic acid derivative as tracer. Ekman, R., Larsson, I., Malmquist, M., Thorell, J.I. Regul. Pept. (1983) [Pubmed]
Regulation of enzyme-substrate complexation by a substrate conjugated with a phospholipid polymer. Takei, K., Konno, T., Watanabe, J., Ishihara, K. Biomacromolecules (2004) [Pubmed]
A sandwich enzyme immunoassay for pulmonary surfactant protein D and measurement of its blood levels in drowning victims. Kamada, S., Seo, Y., Takahama, K. Forensic Sci. Int. (2000) [Pubmed]
Fluorometric determination of pseudocholinesterase activity in postmortem blood samples. Kusu, F., Tsuneta, T., Takamura, K. J. Forensic Sci. (1990) [Pubmed]
A highly specific and sensitive sandwich enzyme immunoassay for human hemoglobin A. Yukawa, N., Kohno, T., Ishikawa, E., Takahama, K. Forensic Sci. Int. (1987) [Pubmed]

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