Disease relevance of Trimethylbenzene

• Developmental toxicity of two trimethylbenzene isomers, mesitylene and pseudocumene, in rats following inhalation exposure [1].
• A new indigenous soil bacterium Pseudomonas sp. growing on phenol and on a mixture of phenol, toluene, o-cresol, naphthalene and 1,2,3-trimethylbenzene (1,2,3-TMB) was isolated and characterized [2].

Psychiatry related information on Trimethylbenzene

• Effects of acute exposure to aromatic hydrocarbons C 9 on locomotor activity in rats. Trimethylbenzene isomers [3].

High impact information on Trimethylbenzene

• Furthermore, DMM and DMH were detected in a urine sample from an individual who did not suffer from occupational exposure to trimethylbenzenes, by using this method [4].
• Toxicokinetics of inhaled trimethylbenzenes in man [5].
• One such application is a mixture of predominantly 9-carbon aromatic molecules (C9 aromatics, primarily isomers of ethyltoluene and trimethylbenzene), which is removed and used as a solvent--High Flash Aromatic Naphtha [6].
• Biological monitoring for trimethylbenzene exposure: a human volunteer study and a practical example in the workplace [7].
• Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50) [8].

Biological context of Trimethylbenzene

• Behavioral effects following subacute inhalation exposure to m-xylene or trimethylbenzene in the rat: a comparative study [9].
• Biological monitoring of experimental human exposure to trimethylbenzene [10].
• These results suggest that (1) AHCs tend to be accumulated from daily exposure, while TMBs do not, (2) the proportions of detected kerosene components in blood can be an indicator of whether the last exposure occurred just before death or not, (3) the kerosene levels last at least 1 day without blood circulation [11].

Anatomical context of Trimethylbenzene

• Greater increases in TMB levels were found in adipose tissue in an exposure duration-dependent manner [12].

Associations of Trimethylbenzene with other chemical compounds

• Gas chromatography/ mass spectroscopy (GC/MS) analysis of the emissions of one pad identified several known irritants (isopropylbenzene, styrene, trimethylbenzene, phenol, and thymol) [13].
• Two weeks after cessation of inhalation exposure to pseudocumene or hemimellitene no recovery in rotarod performance behaviour was observed [14].
• Environmental and biological monitoring revealed that the most significant exposure can be attributed to the following mixture constituents: ethylbenzene, xylene and trimethylbenzene isomers such as pseudocumene, mesitylene and hemimellitene [15].

Analytical, diagnostic and therapeutic context of Trimethylbenzene

• We describe a novel method for the determination of three kinds of dimethylbenzylmercapturic acids (DMM) and six kinds of dimethylhippuric acids (DMH), found in urine as metabolites of trimethylbenzenes, based on liquid chromatography/electrospray ionization tandem mass spectrometry [4].
• Liquid/air partition coefficients (lambda) of the three isomers of trimethylbenzene (1,2,3-,1,2,4-, and 1,3,5-TMB) were determined in vitro using automated head space gas chromatography [16].

References