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Chemical Compound Review:

CHEMBL488336 1-[4-[(1S,2R,3R)-1,2,3,4...

Synonyms: SureCN306015, AG-H-91500, SureCN10040084, KB-19368, CTK8F4038, ...

Gugasyan, R. et al., Reeve, V.E. et al., Gugasyan, R. et al., Iscaro, A. et al., Mandel, T.E. et al., et al.

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Disease relevance of 2-Athbi

A component of the food coloring substance ammonia caramel, 2-acetyl-4-tetrahydroxybutylimidazole (THI), which is known to cause lymphopenia in rats, appears to suppress immunity by a similar pathway when the contact hypersensitivity reaction has been the immune function assay in mice [1].
The compound 2-acetyl-4-tetrahydroxybutylimidazole (THI) is known to suppress a contact hypersensitivity (CH) response [2].
Prevention of splenic granuloma formation in adjuvant arthritis by 2-acetyl-4-tetrahydroxybutylimidazole (THI) [3].
Toxicity studies of Caramel Colour III and 2-acetyl-4(5)-tetrahydroxybutylimidazole in F344 rats [4].

High impact information on 2-Athbi

Emigration of mature T cells from the thymus is inhibited by the imidazole-based compound 2-acetyl-4-tetrahydroxybutylimidazole [5].
The effect of 2-acetyl-4-tetrahydroxybutylimidazole on lymphocyte subsets during a contact hypersensitivity response in the NOD mouse [2].
Effects of the color additive caramel color III and 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI) on the immune system of rats [6].
Prevention of spontaneous and cyclophosphamide-induced diabetes in non-obese diabetic (NOD) mice with oral 2-acetyl-4-tetrahydroxybutylimidazole (THI), a component of caramel colouring III [7].
The effect of 2-acetyl-4-tetrahydroxybutylimidazole on lymphocyte subsets in peripheral blood of the rat [8].

Anatomical context of 2-Athbi

In this study, we examined the ability of 2-acetyl-4-tetrahydroxybutylimidazole (THI), an agent widely used as a component of ammonia caramel food colouring, to inhibit T-cell export from the thymus [5].

Analytical, diagnostic and therapeutic context of 2-Athbi

Determination of 2-acetyl-4(5)-tetrahydroxybutylimidazole in beers by high-performance liquid chromatography with confirmation by chemical derivatization [9].
Accordingly, the haematological effects were studied in mice of oral administration in drinking water of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI), the component of AC responsible for lymphopenia [10].

References

Pyridoxine supplementation protects mice from suppression of contact hypersensitivity induced by 2-acetyl-4-tetrahydroxybutylimidazole (THI), ultraviolet B radiation (280-320 nm), or cis-urocanic acid. Reeve, V.E., Bosnic, M., Boehm-Wilcox, C., Cope, R.B. Am. J. Clin. Nutr. (1995) [Pubmed]
The effect of 2-acetyl-4-tetrahydroxybutylimidazole on lymphocyte subsets during a contact hypersensitivity response in the NOD mouse. Gugasyan, R., Losinno, C., Mandel, T. Immunol. Lett. (1995) [Pubmed]
Prevention of splenic granuloma formation in adjuvant arthritis by 2-acetyl-4-tetrahydroxybutylimidazole (THI). Gugasyan, R., Clouston, D., Mandel, T., Wicks, I. Immunol. Lett. (1997) [Pubmed]
Toxicity studies of Caramel Colour III and 2-acetyl-4(5)-tetrahydroxybutylimidazole in F344 rats. MacKenzie, K.M., Boysen, B.G., Field, W.E., Petsel, S.R., Chappel, C.I., Emerson, J.L., Stanley, J. Food Chem. Toxicol. (1992) [Pubmed]
Emigration of mature T cells from the thymus is inhibited by the imidazole-based compound 2-acetyl-4-tetrahydroxybutylimidazole. Gugasyan, R., Coward, A., O'Connor, L., Shortman, K., Scollay, R. Immunology (1998) [Pubmed]
Effects of the color additive caramel color III and 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI) on the immune system of rats. Houben, G.F., van den Berg, H., Kuijpers, M.H., Lam, B.W., van Loveren, H., Seinen, W., Penninks, A.H. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
Prevention of spontaneous and cyclophosphamide-induced diabetes in non-obese diabetic (NOD) mice with oral 2-acetyl-4-tetrahydroxybutylimidazole (THI), a component of caramel colouring III. Mandel, T.E., Koulmanda, M., Mackay, I.R. Clin. Exp. Immunol. (1992) [Pubmed]
The effect of 2-acetyl-4-tetrahydroxybutylimidazole on lymphocyte subsets in peripheral blood of the rat. Gobin, S.J., Legg, R.F., Paine, A.J., Phillips, J.A. Int. J. Immunopharmacol. (1989) [Pubmed]
Determination of 2-acetyl-4(5)-tetrahydroxybutylimidazole in beers by high-performance liquid chromatography with confirmation by chemical derivatization. Lawrence, J.F., Ménard, C. J. Chromatogr. (1989) [Pubmed]
Lymphopenic effects on mice of a component of ammonia caramel, 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI). Iscaro, A., Mackay, I.R., O'Brien, C. Immunol. Cell Biol. (1988) [Pubmed]

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