Disease relevance of Ba 2742

• Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats [1].
• Contact dermatitis due to Centelase [2].
• Madecassol a new therapy for hepatic fibrosis [3].
• Madecassol has also been shown to have a preventive effect on burn and postoperative hypertrophic scars [4].

Psychiatry related information on Ba 2742

• In the light/dark test, as with 1 mg/kg diazepam, asiaticoside (10 and 20 mg/kg) increased the time spent in the light area and the movement in the light area without altering the total locomotor activity of the animals [5].

High impact information on Ba 2742

• Asiaticoside (AS) derivatives were tested for potential protective effects against Abeta-induced cell death [6].
• Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signaling [7].
• Asiaticoside was determined to induce the phosphorylation of both Smad 2 and Smad 3 [7].
• In addition, we detected the asiaticoside-induced binding of Smad 3 and Smad 4 [7].
• Asiaticoside, a saponin component isolated from Centella asiatica, has been shown to induce type I collagen synthesis in human dermal fibroblast cells [7].

Chemical compound and disease context of Ba 2742

• In this study, the healing effects of Centella asiatica water extract (CE) and asiaticoside (AC), an active constituent of CE, on acetic acid induced gastric ulcers (kissing ulcers) in rats were examined [8].

Biological context of Ba 2742

• BACKGROUND: Asiaticoside, isolated from Centella asiatica, promotes fibroblast proliferation and extracellular matrix (ECM) synthesis in wound healing [9].
• OBJECTIVE: Using cDNA microarray technology, the alteration of gene expression profiles was determined for human dermal fibroblasts in vitro in the presence of asiaticoside (30 microg mL(-1)) [9].
• The comparative steady-state bioavailability of the active ingredients of Madecassol [10].
• This method has been successfully applied to determine the level of asiaticoside in rat plasma and bile samples from pharmacokinetics and biliary excretion studies [11].
• Drug interaction between asiaticoside and some anti-inflammatory drugs in wound healing of the rat [12].

Anatomical context of Ba 2742

• CONCLUSIONS: This information could be used for exploring the response of the target genes to asiaticoside in fibroblasts [9].

Associations of Ba 2742 with other chemical compounds

• Asiatic acid, madecassic acid, and asiaticoside, terpenoids with an ursane skeleton, were tested separately and in combination on skin human fibroblast collagen I synthesis in vitro [13].
• Ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, were isolated from the aerial parts of Centella asiatica (L.) Urban cultivated in Sri Lanka together with madecassoside, asiaticoside, asiaticoside B, and sceffoleoside A [14].
• Titrated extract of Centella asiatica (TECA) contains three principal ingredients, asiaticoside (AS), asiatic acid (AA), and madecassic acid (MA) [15].
• In guinea pig punch wounds topical applications of 0.2% solution of asiaticoside produced 56% increase in hydroxyproline, 57% increase in tensile strength, increased collagen content and better epithelisation [16].
• In streptozotocin diabetic rats, where healing is delayed, topical application of 0.4% solution of asiaticoside over punch wounds increased hydroxyproline content, tensile strength, collagen content and epithelisation thereby facilitating the healing [16].

Gene context of Ba 2742

• In this study, the effects of Centella asiatica water extract (CE) and its active constituent, asiaticoside (AC), on the expression and activity of inducible nitric oxide synthase (iNOS) during gastric ulcer healing in rats were investigated [1].

Analytical, diagnostic and therapeutic context of Ba 2742

• Dermal fibroblast-associated gene induction by asiaticoside shown in vitro by DNA microarray analysis [9].
• Northern blot analysis demonstrated that the CabAS gene is expressed in leaves with no detectable transcript in other plant tissues, consistent with the organ-specific accumulation of the asiaticoside [17].
• After 24 hr, test substances were applied to the defects twice a day: 0.025, 0.25, and 2.5% polysaccharides from PG (PG0.025, 0.25, and 2.5 groups), Madecassol ointment (MC group), aqueous gel (AG group) and no treatment (control group) [18].
• A column-switching high-performance liquid chromatography (HPLC) method is described for the determination of asiaticoside in rat plasma and bile using column-switching and ultraviolet (UV) absorbance detection [11].

References