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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

HSDB 409     ethyl chloromethanoate

Synonyms: AG-F-87131, ANW-44937, KB-51531, LS-69671, BBL011487, ...
 
 
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High impact information on ethyl chloroformate

  • Hydrogenation of the latter gave the amine (25), which was acylated with ethyl chloroformate to give the (ethoxycarbonyl)amino compound 26 [1].
  • Thus, the reaction of the suitable 1-(aminoalkyl)amino-9, 10-dihydro-9-imino-4-nitroacridine 2 with ethyl chloroformate afforded the pyrimidoacridines 3a-f. By hydrolysis in hydrobromic acid of the 10-methoxy derivatives 3d-f, the 10-hydroxy derivatives 3g-i were obtained [2].
  • The R- and S-enantiomers of both parent and 4'-hydroxy metabolite are derivatized with L-leucinamide via an ethyl chloroformate intermediate and subsequently analyzed on a C18 column [3].
  • Analysis of dencichine in Panax notoginseng by gas chromatography-mass spectrometry with ethyl chloroformate derivatization [4].
  • The APAP-BSA adduct, isolated from mouse liver microsomal incubations to which the radiolabeled drug and BSA had been added, was cleaved using a combination of specific (cyanogen bromide) and non-specific (acid hydrolysis) procedures, following which the mixture of amino acids obtained was derivatized, in aqueous solution, with ethyl chloroformate [5].
 

Biological context of ethyl chloroformate

 

Associations of ethyl chloroformate with other chemical compounds

 

Gene context of ethyl chloroformate

 

Analytical, diagnostic and therapeutic context of ethyl chloroformate

References

  1. Synthesis of some glycoside analogs and related compounds from 9-amino-6-(methylthio)-9H-purine. Temple, C., Kussner, C.L., Montgomery, J.A. J. Med. Chem. (1975) [Pubmed]
  2. Pyrimido [4,5,6-kl] acridines, a new class of potential anticancer agents. Synthesis and biological evaluation. Antonini, I., Polucci, P., Cola, D., Bontemps-Gracz, M., Pescalli, N., Menta, E., Martelli, S. Anticancer Drug Des. (1996) [Pubmed]
  3. Stereoselective analysis of fenoprofen and its metabolites. Volland, C., Sun, H., Benet, L.Z. J. Chromatogr. (1990) [Pubmed]
  4. Analysis of dencichine in Panax notoginseng by gas chromatography-mass spectrometry with ethyl chloroformate derivatization. Xie, G.X., Qiu, Y.P., Qiu, M.F., Gao, X.F., Liu, Y.M., Jia, W. Journal of pharmaceutical and biomedical analysis (2007) [Pubmed]
  5. Structural characterization of the major covalent adduct formed in vitro between acetaminophen and bovine serum albumin. Hoffmann, K.J., Streeter, A.J., Axworthy, D.B., Baillie, T.A. Chem. Biol. Interact. (1985) [Pubmed]
  6. Some remarks of penicillin and desacetylcephalosporin synthesis by mixed anhydrides method. Borowicz, P., Eckstein, Z. Polish journal of pharmacology and pharmacy. (1979) [Pubmed]
  7. Synthesis and pharmacological evaluation of acyl derivatives of phenelzine. Coutts, R.T., Mozayani, A., Pasutto, F.M., Baker, G.B., Danielson, T.J. Res. Commun. Chem. Pathol. Pharmacol. (1990) [Pubmed]
  8. Application of ethyl chloroformate derivatization for gas chromatography-mass spectrometry based metabonomic profiling. Qiu, Y., Su, M., Liu, Y., Chen, M., Gu, J., Zhang, J., Jia, W. Anal. Chim. Acta (2007) [Pubmed]
  9. Gas chromatographic method for the determination of urinary acetylpolyamines. Yamamoto, S., Yokogawa, M., Wakamatsu, K., Kataoka, H., Makita, M. J. Chromatogr. (1982) [Pubmed]
 
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