Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AR-1L8056 1-methyl-3-nitroso-urea

Synonyms: AKOS006348905, AC1L3G1K, AC1Q5LE6, 3040-49-1, 1-methyl-3-nitrosourea, ...

Samma, S. et al., Delp, C.R. et al., Richardson, F.C. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of N-Methyl-N'-nitrosourea

This sequence was derived from a region of the Escherichia coli xanthine-guanine phosphoribosyltransferase gene where position 4 is a site frequently mutated by N-methyl-N'-nitrosourea as compared to sites 1-3 [1].
Rapid induction of carcinoma in situ in dog urinary bladder by sequential treatment with N-methyl-N'-nitrosourea and N-butyl-N-(4-hydroxybutyl)-nitrosamine [2].

High impact information on N-Methyl-N'-nitrosourea

Neoplastic transformation and DNA damage of mouse mammary epithelial cells by N-methyl-N'-nitrosourea in organ culture [3].

Chemical compound and disease context of N-Methyl-N'-nitrosourea

A highly atypical intraepithelial proliferation, which was interpreted as carcinoma in situ, developed in the urinary bladder of 2 beagle dogs after repeated intravesical instillations of N-methyl-N'-nitrosourea followed by oral administration of N-butyl-N-(4-hydroxybutyl)nitrosamine [2].

Analytical, diagnostic and therapeutic context of N-Methyl-N'-nitrosourea

Studies were done to determine the ability of N-methyl-N'-nitrosourea (MNU) to transform the mammary cells in organ culture [3].

References

Formation of O6-methyldeoxyguanosine at specific sites in a synthetic oligonucleotide designed to resemble a known mutagenic hotspot. Richardson, F.C., Boucheron, J.A., Skopek, T.R., Swenberg, J.A. J. Biol. Chem. (1989) [Pubmed]
Rapid induction of carcinoma in situ in dog urinary bladder by sequential treatment with N-methyl-N'-nitrosourea and N-butyl-N-(4-hydroxybutyl)-nitrosamine. Samma, S., Uemura, H., Tabata, S., Iwai, A., Nakatsuji, F., Matsuki, H., Babaya, K., Hirao, Y., Okajima, E. Gann = Gan. (1984) [Pubmed]
Neoplastic transformation and DNA damage of mouse mammary epithelial cells by N-methyl-N'-nitrosourea in organ culture. Delp, C.R., Treves, J.S., Banerjee, M.R. Cancer Lett. (1990) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg