Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AGN-PC-0CPWMC 2,2-dimethylhexane

Synonyms: ACMC-1AV0Y, AG-E-95056, AG-G-10041, ANW-33142, FR-2133, ...

Short, B.G. et al., Norton, W.N. et al., Lock, E.A. et al.

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Disease relevance of TRIMETHYLPENTANE

Three groups of 9 Fischer-344 rats each were administered trimethylpentane by gavage twice weekly for 7, 14, or 28 days at a concentration of 1.5 ml/kg body weight [1].
Results of the study indicate that the manifestations of trimethylpentane toxicity among renal cells are associated with the proliferation of hyaline droplets [1].

High impact information on TRIMETHYLPENTANE

This study documents a strong correlation between protein droplet accumulation, single cell necrosis, and regeneration of the male F344 rat nephron during a 3-week exposure regimen to a wide dose range of inhaled UG or gavaged TMP covering several orders of magnitude (2 to 2000 ppm of UG and 0.2 to 50 mg/kg of TMP, respectively) [2].
2,2,4-Trimethylpentane-induced nephrotoxicity. II. The reversible binding of a TMP metabolite to a renal protein fraction containing alpha 2u-globulin [3].

References

The cytotoxic effects of trimethylpentane on rat renal tissue. Norton, W.N., Mattie, D.R. Scanning Microsc. (1987) [Pubmed]
Site-specific renal cytotoxicity and cell proliferation in male rats exposed to petroleum hydrocarbons. Short, B.G., Burnett, V.L., Cox, M.G., Bus, J.S., Swenberg, J.A. Lab. Invest. (1987) [Pubmed]
2,2,4-Trimethylpentane-induced nephrotoxicity. II. The reversible binding of a TMP metabolite to a renal protein fraction containing alpha 2u-globulin. Lock, E.A., Charbonneau, M., Strasser, J., Swenberg, J.A., Bus, J.S. Toxicol. Appl. Pharmacol. (1987) [Pubmed]

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