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Chemical Compound Review

DL-Mandelate     (2R)-2-hydroxy-2-phenyl- ethanoic acid

Synonyms: PubChem6066, PubChem21083, M2209_ALDRICH, CHEMBL292411, SureCN165161, ...
 
 
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Disease relevance of R-MANDELIC ACID

 

Psychiatry related information on R-MANDELIC ACID

  • Generally, the T0-T2 difference in MA was associated (Spearman's Rho) with differences in color vision (p < 0.001), simple reaction time (mean and standard deviation), digit span forward, tension, fatigue and the number of symptoms (p < 0.05); aiming precision showed a similar tendency (p < 0.10) [3].
 

High impact information on R-MANDELIC ACID

  • A transformant able to utilize (R)-mandelate as sole carbon source was characterized, and the plasmid was found to contain approximately five kilobase pairs of P. putida DNA [4].
  • Higher stability of the enzyme at slightly alkaline pH and ambient temperature provides an excellent opportunity to establish a dynamic kinetic resolution process for the production of (R)-(-)-mandelic acid from readily available mandelonitrile [5].
  • The resulting pentafluorobenzyl derivatives of ortho-, meta-, para-cresol, mandelic acid (MA), hippuric acid (HA) and ortho-, meta-, para-methylhippuric acid (MHA) were then quantified by SIM [6].
  • No significant differences of the MA, PGA and HA concentrations in human urine samples obtained by HPLC chromatography on LiChrosorb RP 18 and on Chromolith RP/18e columns were found [7].
  • Preliminary in vivo data indicate the presence of a stereoselective transport system for D(-)-mandelic acid in gastrointestinal tract and possibly kidney [8].

References

  1. Enhancing the catalytic potential of nitrilase from Pseudomonas putida for stereoselective nitrile hydrolysis. Banerjee, A., Kaul, P., Banerjee, U.C. Appl. Microbiol. Biotechnol. (2006) [Pubmed]
  2. Stereoselective nitrile hydrolysis by immobilized whole-cell biocatalyst. Kaul, P., Banerjee, A., Banerjee, U.C. Biomacromolecules (2006) [Pubmed]
  3. Surveillance of early neurotoxic dysfunction. Mergler, D., Huel, G., Bélanger, S., Bowler, R.M., Truchon, G., Drolet, D., Ostiguy, C. Neurotoxicology (1996) [Pubmed]
  4. Cloning, DNA sequence analysis, and expression in Escherichia coli of the gene for mandelate racemase from Pseudomonas putida. Ransom, S.C., Gerlt, J.A., Powers, V.M., Kenyon, G.L. Biochemistry (1988) [Pubmed]
  5. Purification and characterization of an enantioselective arylacetonitrilase from Pseudomonas putida. Banerjee, A., Kaul, P., Banerjee, U.C. Arch. Microbiol. (2006) [Pubmed]
  6. Analysis of urinary biomarkers for exposure to alkyl benzenes by isotope dilution gas chromatographymass spectrometry. Marais, A.A., Laurens, J.B. Journal of separation science. (2005) [Pubmed]
  7. A rapid HPLC method for the determination of carboxylic acids in human urine using a monolithic column. Sperlingová, I., Dabrowská, L., Stránský, V., Tichý, M. Analytical and bioanalytical chemistry. (2004) [Pubmed]
  8. Quantitative gas chromatographic mass spectrometric determination of mandelic acid in blood plasma. Comparison of deuterated and homologous internal standards. Luthe, H., Ludwig-Köhn, H., Langenbeck, U. Biomed. Mass Spectrom. (1983) [Pubmed]
 
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