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Chemical Compound Review:

PubChem3928 4-iodobenzoic acid

Synonyms: SureCN79334, AGN-PC-00E068, CHEMBL101265, NSC-3773, ACMC-1AXEC, ...

Baldwin, R.M. et al., Nygren, C.L. et al., Eisenhut, M. et al.

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High impact information on NSC 3773

The rate-limiting step appears to be deamination to give the transitory intermediate p-iodophenylacetone, which is rapidly degraded to p-iodobenzoic acid and conjugated with glycine in the liver to give the end product of metabolism, p-iodohippuric acid, which is excreted through the kidneys in the urine [1].
The metabolism of 15-(4'-iodophenyl)pentadecanoic acid (IPPA) in the heart muscle is commonly believed to end at 4-iodobenzoic acid as the main and final product of beta-oxidation [2].

Analytical, diagnostic and therapeutic context of NSC 3773

The solid-state structure of 4-iodobenzoic acid has been confirmed by variable temperature X-ray diffraction, variable temperature solid-state NMR and differential scanning calorimetry [3].

References

In vivo chemistry of iofetamine HCl iodine-123 (IMP). Baldwin, R.M., Wu, J.L. J. Nucl. Med. (1988) [Pubmed]
Metabolism of 15-(4'-[123I]iodophenyl)pentadecanoic acid ([123I]IPPA) in the rat heart; identification of new metabolites by high pressure liquid chromatography and fast atom bombardment-mass spectrometry. Eisenhut, M., Lehmann, W.D., Sütterle, A. Nucl. Med. Biol. (1993) [Pubmed]
On the solid state structure of 4-iodobenzoic acid. Nygren, C.L., Wilson, C.C., Turner, J.F. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2005) [Pubmed]

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